Comparative Study between Intravenous Lidocaine and Fentanyl in Attenuating Cardiovascular Response To laryngoscopic Intubation in Adult Patients Undergoing Elective Surgery in Tikur Anbessa Specialized Hospital
No Thumbnail Available
Date
2024-04
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa University
Abstract
Background: Endotracheal intubation is done for various indications and maintaining the airway
during general anesthesia is one of them. Though intubation is seldom eventful in a healthy
individual with no comorbidity, it can complicate patient’s condition if the procedure isn’t
smooth. So blunting hemodynamic responses due to the laryngoscopy and intubation is
recommended during these procedures. Several pharmacologic agents have been recommended
such as: opioids, local anesthetics, beta blockers and deepening inhalational agents. This study
tries to compare fentanyl and lidocaine in attenuating those hemodynamic responses.
Objective: To compare the effectiveness of fentanyl and lidocaine in attenuating hemodynamic
response to laryngoscopy and intubation in Tikur Anbessa specialized hospital.
Method: Institution based randomized control trial was be done in Tikur Anbessa specialized
hospital from July 1 to September 30. 86 Patients were assigned into two groups: 43 patients
were assigned as Group F and as Group L. the fentanyl group were given 2μ/kg and the lidocaine
group took 1.5 mg/kg (2%). Data was collected from the chart and observation of the anesthesia
monitor. Data was personally verified for accuracy before being coded and placed into SPSS.
With the aid of the computer program SPSS version 25, data was cleaned and examined. The
analysis was done using chi square test for the socio demographic data and independent t test
was used to assess the mean and standard deviation for the two groups of the participants. For all
analyses, a P value of 0.05 or lower is regarded as statistically significant.
Result: there was no significant difference between the groups in regard to socio demographic
data and baseline hemodynamic parameters. The mean and SD of the1st minute HR is
93.65+12.32 and 98.23+10.19 for fentanyl and lidocaine respectively. The p value of the first
minute HR between the two groups is 0.064. There is no significant difference between the
groups at 1st, 3rd and 5th minute. There is significant difference regarding the first minute SBP,
DBP and MAP with a p value of < 0.05. Otherwise the p value for third and fifth minute is
insignificant.
Conclusion: the blunting capacity of fentanyl is superior to lidocaine especially on the
hypertensive response to laryngoscopic intubation of the first minute. Even though the
result doesn’t indicate significance, the HR response is better attenuated with fentanyl.
Description
Keywords
Adult Patients, Endotracheal intubation, Fentanyl, Lidocain