Comparative Study between Intravenous Lidocaine and Fentanyl in Attenuating Cardiovascular Response To laryngoscopic Intubation in Adult Patients Undergoing Elective Surgery in Tikur Anbessa Specialized Hospital
| dc.contributor.advisor | Tilahun,Rahel(MD) | |
| dc.contributor.advisor | Birhanu,Tseganesh(MD) | |
| dc.contributor.author | Kenea,Mezmure | |
| dc.date.accessioned | 2025-08-13T07:35:31Z | |
| dc.date.available | 2025-08-13T07:35:31Z | |
| dc.date.issued | 2024-04 | |
| dc.description.abstract | Background: Endotracheal intubation is done for various indications and maintaining the airway during general anesthesia is one of them. Though intubation is seldom eventful in a healthy individual with no comorbidity, it can complicate patient’s condition if the procedure isn’t smooth. So blunting hemodynamic responses due to the laryngoscopy and intubation is recommended during these procedures. Several pharmacologic agents have been recommended such as: opioids, local anesthetics, beta blockers and deepening inhalational agents. This study tries to compare fentanyl and lidocaine in attenuating those hemodynamic responses. Objective: To compare the effectiveness of fentanyl and lidocaine in attenuating hemodynamic response to laryngoscopy and intubation in Tikur Anbessa specialized hospital. Method: Institution based randomized control trial was be done in Tikur Anbessa specialized hospital from July 1 to September 30. 86 Patients were assigned into two groups: 43 patients were assigned as Group F and as Group L. the fentanyl group were given 2μ/kg and the lidocaine group took 1.5 mg/kg (2%). Data was collected from the chart and observation of the anesthesia monitor. Data was personally verified for accuracy before being coded and placed into SPSS. With the aid of the computer program SPSS version 25, data was cleaned and examined. The analysis was done using chi square test for the socio demographic data and independent t test was used to assess the mean and standard deviation for the two groups of the participants. For all analyses, a P value of 0.05 or lower is regarded as statistically significant. Result: there was no significant difference between the groups in regard to socio demographic data and baseline hemodynamic parameters. The mean and SD of the1st minute HR is 93.65+12.32 and 98.23+10.19 for fentanyl and lidocaine respectively. The p value of the first minute HR between the two groups is 0.064. There is no significant difference between the groups at 1st, 3rd and 5th minute. There is significant difference regarding the first minute SBP, DBP and MAP with a p value of < 0.05. Otherwise the p value for third and fifth minute is insignificant. Conclusion: the blunting capacity of fentanyl is superior to lidocaine especially on the hypertensive response to laryngoscopic intubation of the first minute. Even though the result doesn’t indicate significance, the HR response is better attenuated with fentanyl. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/6603 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Adult Patients | |
| dc.subject | Endotracheal intubation | |
| dc.subject | Fentanyl | |
| dc.subject | Lidocain | |
| dc.title | Comparative Study between Intravenous Lidocaine and Fentanyl in Attenuating Cardiovascular Response To laryngoscopic Intubation in Adult Patients Undergoing Elective Surgery in Tikur Anbessa Specialized Hospital | |
| dc.type | Thesis |