The Magnitude and Determinants of Sepsis and Septic Shock Among Adult Patients Admitted to Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia
| dc.contributor.advisor | Wondwossen Amogne | |
| dc.contributor.author | Hikma Fekadu | |
| dc.date.accessioned | 2025-03-20T14:03:35Z | |
| dc.date.available | 2025-03-20T14:03:35Z | |
| dc.date.issued | 2024-10-23 | |
| dc.description.abstract | Problem statement - Sepsis is defined as host immune dysregulation in response to an infection causing organ dysfunction. Globally more than 5 million deaths due to sepsis occur every year. In Ethiopia, the prevalence from one multicenter study conducted in ICUs was 26.5/ 100 ICU admissions. No studies outside the ICU and wards, such as the ED, have been conducted in Ethiopia. This study will reflect the burden of community-acquired sepsis and associated factors. Objectives- To determine the magnitude and associated factors of sepsis and septic shock among adult patients in Tikur Anbesa Specialized Hospital Emergency Department (TASH ED), Addis Ababa, Ethiopia. Methods – We used a Hospital-based prospective observational study using secondary data from medical records of patient charts. The study was conducted in Tikur Anbesa Specialized Hospital Emergency Department, Addis Ababa, Ethiopia from February 2024 to April 2024. Adult patients who visited the Emergency Department with complete medical records were included during the study period. A sample size of 400 was analyzed. A simple random sampling technique was used and patients were randomly selected by lottery. Data was kept confidentially and analyzed by Stata. Results: among the 400 total included patients the prevalence of sepsis and septic shock account for 25.25%, and 5.5% of emergency department admissions respectively. The median age was 41 and males accounted for 216 (54%). The most common site of infection was unknown followed by respiratory and intra-abdominal infections (36%, 28%, and 24% respectively). Comorbidity was identified in 67.8% of patients with malignancy being the most frequent 22.25%. Organ failure was noted in 12% of the patients. Risk factors associated with the prevalence of sepsis include >50 years (AOR 2.8, 95% CI = 1.19-6.696), malignancy (AOR 5.54, 95% CI = 2.63-11.648), and organ failure (AOR 5.77, 95% CI =2.63-12.66). Conclusion: The prevalence of sepsis and septic shock is 25.25% and 5.5% respectively in the emergency department of TASH. The factors associated with sepsis are age above 50, malignancy, and associated organ dysfunction. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/5162 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Magnitude and determinants of sepsis | |
| dc.title | The Magnitude and Determinants of Sepsis and Septic Shock Among Adult Patients Admitted to Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia | |
| dc.type | Thesis |