Evaluation of anti-malarial activity of 80% methanol extract and solvent fractions of the leaves of Olea europaea Linn (Oleaceae) in mice
| dc.contributor.advisor | Engidawork, Ephrem(PhD) | |
| dc.contributor.author | Misganaw, Desye | |
| dc.date.accessioned | 2018-07-11T08:02:46Z | |
| dc.date.accessioned | 2023-11-05T14:42:42Z | |
| dc.date.available | 2018-07-11T08:02:46Z | |
| dc.date.available | 2023-11-05T14:42:42Z | |
| dc.date.issued | 2017-02 | |
| dc.description.abstract | Evaluation of the anti-malarial activity of 80% methanol extract and solvent fractions of the leaves of Olea europaea (Oleaceae) in mice Desye Misganaw Addis Ababa University, 2016 Drug resistance posed a challenge to malaria control measures. This called for development and discovery of new chemotherapeutic agents from alternative sources such as medicinal plants. This study aimed to investigate antimalarial activity of Olea europaea, an extensively used plant in Ethiopian folklore medicine. The leaf was extracted by maceration using 80% methanol and the crude extract was then successively fractionated using solvents of differing polarity (chloroform, n-butanol and water). Antimalarial activity of various doses of the extract and fractions (200, 400 and 600 mg/kg) was evaluated using the 4-day suppressive test (both crude and fractions), as well as Rane’s and prophylactic tests (crude extract only). The crude extract significantly reduced parasitemia (p<0.001) and prolonged survival time (p<0.001) in all models, as compared to the negative control group. Accordingly, percentage suppression was highest on the 4- day suppressive test followed by the Rane’s test and then the prophylactic test. The nbutanol fraction produced the highest percentage inhibition of parasitemia among the fractions, while the aqueous fraction was the least and the rank was also similar for other parameters (packed cell volume, rectal temperature and body weight) as well. Hence, this study revealed the anti-malarial activity of the crude extract of the leaves of Olea europaea and further shown that all the three fractions possessed varying degree of antimalarial activity. Key words: Antimalarial activity, Plasmodium berghei, Olea europaea | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/7903 | |
| dc.language.iso | en | en_US |
| dc.publisher | Addis Abeba Universty | en_US |
| dc.subject | Antimalarial activity, Plasmodium berghei, Olea europaea | en_US |
| dc.title | Evaluation of anti-malarial activity of 80% methanol extract and solvent fractions of the leaves of Olea europaea Linn (Oleaceae) in mice | en_US |
| dc.type | Thesis | en_US |