Prevalence and antibiotic susceptibility pattern of methicillinresistant staphylococcus aureus colonization among clinically tuberculosis suspected clients at St.Peter specialized hospital Addis Ababa Ethiopia.
| dc.contributor.advisor | Desta, Kassu (BSc, MSc, PhD fellow, Assistant professor) | |
| dc.contributor.author | Kubi, Akele | |
| dc.date.accessioned | 2019-04-11T07:03:32Z | |
| dc.date.accessioned | 2023-11-06T08:56:24Z | |
| dc.date.available | 2019-04-11T07:03:32Z | |
| dc.date.available | 2023-11-06T08:56:24Z | |
| dc.date.issued | 2018-10 | |
| dc.description.abstract | Background: The burden of methicillin resistant S. aureus is a major public health concern worldwide; which are challenging both for physicians and patients due to limited choice of therapeutic options and increased cost of care. However there is little information regarding the presence and antibiotic resistance pattern of MRSA colonization on the clinically TB suspected clients. Objective: The aim of this study was to determine the nasal colonization and antimicrobial resistance patterns of MRSA isolates among clinically tuberculosis suspected clients at St. Peter Hospital Addis Ababa, Ethiopia. Methods: A hospital based cross-sectional study was conducted from April to July, 2018. A total of 281 Nasal swabs were collected, transported and processed using both SBA and MSA. Disk diffusion method was used for antimicrobial susceptibility testing. MRSA was detected using Cefoxitin(30μg) discs and data related with risk factors were gathered using structured questionnaires. Association of risk factors with colonization of S. aureus/MRSA was assessed using univariate and multivariate logistic regression. A p-value <0.05 was taken as statistically significant association. Data entry and statistical analysis were done using SPSS V-23. Results: Of 110 S. aureus isolates, 34(30.1%) were MRSA strains. The main risk factor for nasal colonization of S. aureus in the study area was recent hospitalization. The Susceptibility profiles of MRSA isolates were (85.6%) susceptible to Chloramphenicol, Ciprofloxacin (76.5%), Clindamycin (67.6%), Erythromycin (64.7%), Gentamycin (91.2%), Trimethoprimsulphamethoxazole (67.6%) and Tetracycline (11.8%). All the MRSA isolates were resistant to Penicillin and sensitive to Vancomicin. Conclusion: High prevalence of S. aureus/ MRSA colonization among tuberculosis suspected clients which suggest a need of attention of the problem in tuberculosis suspected clients. Though only recent hospitalization was associated with S. aureus, colonization by MRSA was not associated with any one of the variables. MRSA isolates were highly resistant to penicillin and highly sensitive to Vancomicin. Further studies are needed on public health significance of MRSA at regional and national level. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/17816 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | S.aureus, MRSA, Nasal colonization, associated risk factors. | en_US |
| dc.title | Prevalence and antibiotic susceptibility pattern of methicillinresistant staphylococcus aureus colonization among clinically tuberculosis suspected clients at St.Peter specialized hospital Addis Ababa Ethiopia. | en_US |
| dc.type | Thesis | en_US |