Patterns of Hodgkin’s lymphoma: epidemiology, clinical presentation, histologic subtypes, prognostic factors, and treatment outcome in TASH from December 2010 to december2015.
| dc.contributor.advisor | Dr.Kebede, Seifu (MD, Assistant professor in medicine ,internist and Consultant in Hematologist) | |
| dc.contributor.author | Abate, Hiluf | |
| dc.date.accessioned | 2021-01-24T08:47:56Z | |
| dc.date.accessioned | 2023-11-05T09:37:01Z | |
| dc.date.available | 2021-01-24T08:47:56Z | |
| dc.date.available | 2023-11-05T09:37:01Z | |
| dc.date.issued | 2019-11 | |
| dc.description.abstract | Background: Hodgkin lymphoma (HL) exhibits considerable clinico pathological variations in different parts of the world. This study was prompted by the limited availability of HL data in developing countries (particularly long-term outcomes). Methodology: This is hospital based retrospective study of 96 patients diagnosed and treated with HL at TASH, from December 2010 to December 2015, at department of internal medicine, hematology unit. Patient records and phone interviewing was used to collect data. Results: The study included 96 patients with a median age of 24 years (range14–60 years); 58% of patients were between ages 14-25. 71 % were male, male to female ratio of 2.4. The most common primary presentation was peripheral lymphadenopathy (93%), the neck lymph nodes were primary complaints in 75% of patients. B symptoms occurred in 63% .71% had an advanced stage, 25% had bulky disease. Mixed Cellularity was the most common histological subtype (52%). Initial therapy outcomes were complete response, progressive disease, partial response, and in 84%, 8%, and 7% of patients, respectively. The mean follow up patients from patient records was 12 months, from phone interviews 36 months. The 5 year overall survival (OS) 81%., and progression free survival (PFS) was and 70%.Multivariate analysis showed that treatment discontinuation was independently associated with death. Conclusion: Hodgkin’s Lymphoma follows epidemiological and clinical features of developing countries at our center. The 5-year overall and progression-free survivals were below international rates. Treatment adherence significantly contributes to overall survival. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/24801 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Hodgkin’s Lymphoma, clinical pattern, survival analysis, Ethiopia. | en_US |
| dc.title | Patterns of Hodgkin’s lymphoma: epidemiology, clinical presentation, histologic subtypes, prognostic factors, and treatment outcome in TASH from December 2010 to december2015. | en_US |
| dc.type | Thesis | en_US |