Patterns of Hodgkin’s lymphoma: epidemiology, clinical presentation, histologic subtypes, prognostic factors, and treatment outcome in TASH from December 2010 to december2015.
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Date
2019-11
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Addis Abeba University
Abstract
Background:
Hodgkin lymphoma (HL) exhibits considerable clinico pathological variations in different parts
of the world. This study was prompted by the limited availability of HL data in developing
countries (particularly long-term outcomes).
Methodology:
This is hospital based retrospective study of 96 patients diagnosed and treated with HL at TASH,
from December 2010 to December 2015, at department of internal medicine, hematology unit.
Patient records and phone interviewing was used to collect data.
Results:
The study included 96 patients with a median age of 24 years (range14–60 years); 58% of
patients were between ages 14-25. 71 % were male, male to female ratio of 2.4. The most
common primary presentation was peripheral lymphadenopathy (93%), the neck lymph nodes
were primary complaints in 75% of patients. B symptoms occurred in 63% .71% had an
advanced stage, 25% had bulky disease. Mixed Cellularity was the most common histological
subtype (52%). Initial therapy outcomes were complete response, progressive disease, partial
response, and in 84%, 8%, and 7% of patients, respectively. The mean follow up patients from
patient records was 12 months, from phone interviews 36 months. The 5 year overall survival
(OS) 81%., and progression free survival (PFS) was and 70%.Multivariate analysis showed that
treatment discontinuation was independently associated with death.
Conclusion:
Hodgkin’s Lymphoma follows epidemiological and clinical features of developing countries at
our center. The 5-year overall and progression-free survivals were below international rates.
Treatment adherence significantly contributes to overall survival.
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Keywords
Hodgkin’s Lymphoma, clinical pattern, survival analysis, Ethiopia.