Prevalence and Drug Susceptibility Pattern of Group A Streptococcus among Patients with Tonsillopharyngitis Attending Yekatit 12 Hospital, Addis Ababa, Ethiopia
| dc.contributor.advisor | Tesfaye, Abraham (PhD) | |
| dc.contributor.advisor | Diriba, Regasa (MSc) | |
| dc.contributor.author | Selbane, Terefe | |
| dc.date.accessioned | 2021-12-06T07:00:25Z | |
| dc.date.accessioned | 2023-11-06T08:57:12Z | |
| dc.date.available | 2021-12-06T07:00:25Z | |
| dc.date.available | 2023-11-06T08:57:12Z | |
| dc.date.issued | 2021-03 | |
| dc.description.abstract | Background: The group A streptococcus causes different spectrum of human infections, ranging from pharyngitis and pyoderma, to life threatening immunological complications such as acute rheumatic fever, rheumatic heart disease, post streptococcal glomerulonephritis, toxic shock syndrome and necrotizing fasciitis. The greatest global burden of group A streptococcus disease is due to Rheumatoid Heart Disease which follows group A streptococcus pharyngitis, where 15 million cases and 349,000 deaths occur worldwide. Objective: To determine the prevalence, drug susceptibility pattern of group A streptococcus and possible associated risk factors among patients with Tonsillopharyngitis attending Yekatit 12 Hospital, Addis Ababa, Ethiopia. Methods: A cross-sectional study was conducted on 192 participants with Tonsillopharyngitis who attended Yekatit 12 hospital Ear Nose Throat clinic in the city of Addis Ababa, Ethiopia from July 2020 to October 2021 and throat swab sample was collected. A standard microbiological method was used to isolate and identify group A streptococcus from throat swabs obtained from study subjects. The disk diffusion method was used for antimicrobial susceptibility testing. Descriptive statistics and multivariate logistic regression analysis were done by Statistical Package Social Science version 26. Results: In this study, the overall prevalence of group A streptococcus was 3.65% (7/192).All isolates of GAS were susceptible to all penicillin (10unit), Clindamycin (2µg), Chloramphenicol (30 µg), Vancomycin (30µg), erythromycin (15 µg), Tetracycline (30 µg) while resistance to Trimethoprimsulfametoxazole (1.25/23.75µg). None of the risk factors were found to be significantly associated with strep-throat Tonsillopharyngitis [P>0.05]. Conclusion: In this study the prevalence of group A streptococcus was relatively low. All group A streptococcus isolates remained susceptible to penicillin, Clindamycin, erythromycin, Chloramphenicol, tetracycline and Vancomycin indicating that those are still the drug of choice for the treatment of GAS infection. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/29112 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Group A Streptococcus, Bet–hemolytic, Drug Resistance, Prevalence, Tonsillopharyngitis, Ethiopia | en_US |
| dc.title | Prevalence and Drug Susceptibility Pattern of Group A Streptococcus among Patients with Tonsillopharyngitis Attending Yekatit 12 Hospital, Addis Ababa, Ethiopia | en_US |
| dc.type | Thesis | en_US |