Prevalence and Drug Susceptibility Pattern of Group A Streptococcus among Patients with Tonsillopharyngitis Attending Yekatit 12 Hospital, Addis Ababa, Ethiopia
| dc.contributor.advisor | Tesfaye Abraham | |
| dc.contributor.advisor | Diriba Regasa | |
| dc.contributor.author | Selbane Terefe | |
| dc.date.accessioned | 2021-12-06T07:00:25Z | |
| dc.date.accessioned | 2023-11-06T08:57:12Z | |
| dc.date.available | 2021-12-06T07:00:25Z | |
| dc.date.available | 2023-11-06T08:57:12Z | |
| dc.date.issued | 2021-03 | |
| dc.description.abstract | Background: The group A streptococcus causes different spectrum of human infections, ranging from pharyngitis and pyoderma, to life threatening immunological complications such as acute rheumatic fever,rheumatic heart disease, post streptococcal glomerulonephritis, toxic shock syndrome and necrotizingfasciitis. The greatest global burden of group A streptococcus disease is due to Rheumatoid Heart Diseasewhich follows group A streptococcus pharyngitis, where 15 million cases and 349,000 deaths occurworldwide. Objective: To determine the prevalence, drug susceptibility pattern of group A streptococcus and possibleassociated risk factors among patients with Tonsillopharyngitis attending Yekatit 12 Hospital, AddisAbaba, Ethiopia. Methods: A cross-sectional study was conducted on 192 participants with Tonsillopharyngitis whoattended Yekatit 12 hospital Ear Nose Throat clinic in the city of Addis Ababa, Ethiopia from July 2020to October 2021 and throat swab sample was collected. A standard microbiological method was used toisolate and identify group A streptococcus from throat swabs obtained from study subjects. The diskdiffusion method was used for antimicrobial susceptibility testing. Descriptive statistics and multivariatelogistic regression analysis were done by Statistical Package Social Science version 26. Results: In this study, the overall prevalence of group A streptococcus was 3.65% (7/192).All isolates ofGAS were susceptible to all penicillin (10unit), Clindamycin (2µg), Chloramphenicol (30 µg),Vancomycin (30µg), erythromycin (15 µg), Tetracycline (30 µg) while resistance to Trimethoprimsulfametoxazole(1.25/23.75µg). None of the risk factors were found to be significantly associated withstrep-throat Tonsillopharyngitis [P>0.05]. Conclusion: In this study the prevalence of group A streptococcus was relatively low. All group Astreptococcus isolates remained susceptible to penicillin, Clindamycin, erythromycin, Chloramphenicol,tetracycline and Vancomycin indicating that those are still the drug of choice for the treatment of GASinfection. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/29112 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Group A Streptococcus, Bet–hemolytic, Drug Resistance, Prevalence, Tonsillopharyngitis, Ethiopia | en_US |
| dc.title | Prevalence and Drug Susceptibility Pattern of Group A Streptococcus among Patients with Tonsillopharyngitis Attending Yekatit 12 Hospital, Addis Ababa, Ethiopia | en_US |
| dc.type | Thesis | en_US |