Species Distribution and Antifungal Susceptibility Profile of Yeasts Recovered from Different Clinical Samples at Arsho laboratory, Addis Ababa, Ethiopia.

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dc.contributor.advisorBitew Adane
dc.contributor.advisormihret Amete
dc.contributor.authorSeyoum Elias
dc.date.accessioned2020-02-11T13:00:54Z
dc.date.accessioned2023-11-06T08:56:25Z
dc.date.available2020-02-11T13:00:54Z
dc.date.available2023-11-06T08:56:25Z
dc.date.issued2019-01
dc.description.abstractBackground: Currently, fungal diseases of humans are among the most problematic illnesses isthe result of an increase in opportunistic fungal infections caused by rise in the number ofimmune-compromised patients. Particularly, yeasts are the most common cause of fungalinfections leading to a range superficial type to life-threatening invasive infections. The aim ofthis study is to determine species distribution and antifungal susceptibility profile of yeastsparticularly of Candida species recovered from different clinical samples. Method: A cross sectional study was conducted from January 01, 2018 –September 30, 2018 inAddis Ababa, Arsho laboratory. Oropharengial swabs ,nail scrapings, sputum, corneal scrapings,and vaginal swabs were collected from patients with signs and symptoms of i nfections.Identification and antifungal susceptibility testing was performed by using YST and AST-YS07card through VITEK 2 compact system. Data was entered and analyzed using SPSS version 20. Result: A total of 209 yeasts were recovered of which 49.8% were Candida albicans, 43.1%were non-albicans candida species and 7.2% were yeasts other than Candida species. Thecurrent study, eighteen (18) different types of yeast species were identified from different clinicalsamples. All recognized yeast considered as a causative agent of fungal infection in previouslyreported data in worldwide. Entire isolates of 85.6 %, 99.4 %, 98.8 %, 98.8 %, 86.2 % weresusceptible to fluconazoleVoriconazolemicafungin,Caspofungin , and flucytosine, respectively.Candida albicans isolates were 100% susceptible to voriconazole, caspofungin, and micafungin. As of whole isolates were showed 1.6 % cross-resistance and 8.6 % multi drug-resistance. Conclusion: C. albicans remaining the predominant species, but the emergence of non-albicansCandida and other than candida species have increased .In vitro-resistance to fluconazole,voriconazole and flucytosine was rare among C. albicans.However, an increase of nonsusceptibilitywasobservedamongC.krusieandC.rugosaforfluconazoleandflucytosine.Thus,morestudiesonCandidaprevalenceanddrugsusceptibilityareneededthroughoutcountry. en_US
dc.identifier.urihttp://etd.aau.edu.et/handle/123456789/20605
dc.language.isoen_USen_US
dc.publisherAddis Abeba Universityen_US
dc.subjectCandida albicans,Non- albican candida species,Candidasis,Antifungal susceptibilityen_US
dc.titleSpecies Distribution and Antifungal Susceptibility Profile of Yeasts Recovered from Different Clinical Samples at Arsho laboratory, Addis Ababa, Ethiopia.en_US
dc.typeThesisen_US

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