Species Distribution and Antifungal Susceptibility Profile of Yeasts Recovered from Different Clinical Samples at Arsho laboratory, Addis Ababa, Ethiopia.
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Date
2019-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba University
Abstract
Background: Currently, fungal diseases of humans are among the most problematic illnesses is
the result of an increase in opportunistic fungal infections caused by rise in the number of
immune-compromised patients. Particularly, yeasts are the most common cause of fungal
infections leading to a range superficial type to life-threatening invasive infections. The aim of
this study is to determine species distribution and antifungal susceptibility profile of yeasts
particularly of Candida species recovered from different clinical samples.
Method: A cross sectional study was conducted from January 01, 2018 –September 30, 2018 inAddis Ababa, Arsho laboratory. Oropharengial swabs ,nail scrapings, sputum, corneal scrapings,
and vaginal swabs were collected from patients with signs and symptoms of i nfections.Identification and antifungal susceptibility testing was performed by using YST and AST-YS07
card through VITEK 2 compact system. Data was entered and analyzed using SPSS version 20.
Result: A total of 209 yeasts were recovered of which 49.8% were Candida albicans, 43.1%were non-albicans candida species and 7.2% were yeasts other than Candida species. Thecurrent study, eighteen (18) different types of yeast species were identified from different clinicalsamples. All recognized yeast considered as a causative agent of fungal infection in previously
reported data in worldwide. Entire isolates of 85.6 %, 99.4 %, 98.8 %, 98.8 %, 86.2 % were
susceptible to fluconazole,Voriconazole,micafungin,Caspofungin , and flucytosine, respectively.Candida albicans isolates were 100% susceptible to voriconazole, caspofungin, and micafungin. As of whole isolates were showed 1.6 % cross-resistance and 8.6 % multi drug-resistance.
Conclusion: C. albicans remaining the predominant species, but the emergence of non-albicansCandida and other than candida species have increased .In vitro-resistance to fluconazole,voriconazole and flucytosine was rare among C. albicans.However, an increase of nonsusceptibility
was
observed
among
C.
krusie
and
C.rugosa
for
fluconazole
and
flucytosine.
Thus,more
studies
on
Candida
prevalence
and
drug
susceptibility
are
needed
throughout
country.
Description
Keywords
Candida albicans,Non- albican candida species,Candidasis,Antifungal susceptibility