Establishment of Reference Interval for Hemoglobin A1c and Fructosamine for Apparently Healthy Adults in Addis Ababa, Ethiopia.
| dc.contributor.advisor | Tsegaye Aster | |
| dc.contributor.advisor | Kinde Samuel | |
| dc.contributor.advisor | Challa Feyissa | |
| dc.contributor.author | Getahun Tigist | |
| dc.date.accessioned | 2021-01-03T10:48:44Z | |
| dc.date.accessioned | 2023-11-06T08:56:43Z | |
| dc.date.available | 2021-01-03T10:48:44Z | |
| dc.date.available | 2023-11-06T08:56:43Z | |
| dc.date.issued | 2020-07 | |
| dc.description.abstract | Background: HbA1c and fructosamine used for diabetes monitor and control as a glycemiccontrol. The absence of locally derived referenc intervals for these parameters from apparenetlyhealth subjects for the local will impact on the physician, laboratories, and researchers. Objective: to establish reference interval for hemoglobin A1c andfructosamine for apparentlyhealthy adults in Addis Ababa, Ethiopia. Methodology: A cross sectional study was conducted in four selected sub-cities (Akaki, Kirkos,Arada, Yeka), Addis Ababa, Ethiopia from December 2019 to April 2020. The study wasincluding study participants with 18 and above years of age. Blood sample was collected andanalyzed by using Cobas 6000(c 501) instrument. Both Kolmogorov–Sminorv, and ManWhitneytestwereanalyzedtocheckthedatanormalitydistribution and partitions, respectively.Reference intervals, lower 2.5th percentile and 97.5th percentile for the upper, (overall, andspecific for sex and age) weredetermined using non-parametric methods. Result: - Out of the total 344 participants, 256 (121 males, 135 females,) study participants aged18-60 years participated in this study. Reference interval was established from 4.70 – 6.27% and 203 - 321mol/L for HbA1c, and fructosamine, respectively. There was weak associationbetween HbA1c and age (r=0.1803, p=0.0378). Conclusion: This study established reference intervals for both HbA1c and Fructosamine foradult population using the current available equipment platform. The established referenceinterval is applicable for the currentpractice in the country to diagnosis, treatment, and monitor of diabetics mellitus. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/24520 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Hemoglobin A1c, fructosamine, reference interval, Ethiopia. | en_US |
| dc.title | Establishment of Reference Interval for Hemoglobin A1c and Fructosamine for Apparently Healthy Adults in Addis Ababa, Ethiopia. | en_US |
| dc.type | Thesis | en_US |