Establishment of Reference Interval for Hemoglobin A1c and Fructosamine for Apparently Healthy Adults in Addis Ababa, Ethiopia.
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Date
2020-07
Authors
Journal Title
Journal ISSN
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Publisher
Addis Abeba University
Abstract
Background: HbA1c and fructosamine used for diabetes monitor and control as a glycemic
control. The absence of locally derived referenc intervals for these parameters from apparenetly
health subjects for the local will impact on the physician, laboratories, and researchers.
Objective: to establish reference interval for hemoglobin A1c and fructosamine for apparently
healthy adults in Addis Ababa, Ethiopia.
Methodology: A cross sectional study was conducted in four selected sub-cities (Akaki, Kirkos,
Arada, Yeka), Addis Ababa, Ethiopia from December 2019 to April 2020. The study was
including study participants with 18 and above years of age. Blood sample was collected and
analyzed by using Cobas 6000(c 501) instrument. Both Kolmogorov–Sminorv, and MannWhitney
test
were
analyzed
to
check
the
data
normality
distribution and partitions, respectively.
Reference intervals, lower 2.5
th
percentile and 97.5
th
percentile for the upper, (overall, and
specific for sex and age) were determined using non-parametric methods.
Result: - Out of the total 344 participants, 256 (121 males, 135 females,) study participants aged
18-60 years participated in this study. Reference interval was established from 4.70 – 6.27% and
203 - 321mol/L for HbA1c, and fructosamine, respectively. There was weak association
between HbA1c and age (r=0.1803, p=0.0378).
Conclusion: This study established reference intervals for both HbA1c and Fructosamine for
adult population using the current available equipment platform. The established reference
interval is applicable for the current practice in the country to diagnosis, treatment, and monitor
of diabetics mellitus.
Description
Keywords
Hemoglobin A1c, fructosamine, reference interval, Ethiopia.