Assessment of clinical profile and outcome of patients with acute coronary syndrome in Tikur Anbessa and AaBET Hospitals ,Addis Abeba, Ethiopia.
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Date
2018-07
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Addis Abeba University
Abstract
Background: Coronary artery disease (CAD) is the leading cause of mortality and
morbidity in the world. Although no countrywide study has been done on
cardiovascular disease (CVD) in Ethiopia some hospital based studies have shown
the incidence of CVD is progressively increasing.
Methodology: A retrospective cross sectional study was conducted on the clinical
profile of patients with Acute Coronary Syndrome (ACS) In Tikur Anbessa and
AaBET hospitals using a structured questionnaire from January 2016 to February
2018. The data were entered, analyzed and interpreted using SPSS version 20
software.
Result: Of 142 patients with ACS, 62 (48.6%) were diagnosed as STEMI. The
mean age was 57.5±12.09 years. The average time from onset of ACS symptoms
to presentation in the emergency department was 2.4 days (61.96 hours) ±48.85. In
about 101 (71.1%) patients, hypertension was identified as a risk factor for
development of ACS. Nearly fifteen percent (14.8 %) of ACS patients in Tikur
Anbessa and AaBET hospitals were either Killip class III or IV. The in-hospital
mortality was 9.8%. Predictors of inhospital mortality in Tikur Anbessa and
AaBET hospitals included female sex (P=0.016), time from symptom onset to
presentation (P=0.04), being Killip class III and IV (P=0.001), and STEMI
diagnosis (P=0.018).
Conclusion: Patients with ACS have delayed presentation to the hospital from
onset of symptoms. Patients had similar risk profiles with the developed world, but
have higher mortality. Being female, delayed presentation, having STEMI, and
higher Killip class was found to be independent predictors of in hospital mortality
in Tikur Anbessa and AaBET Hospitals.
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Keywords
Acute coronary syndrome, Ethiopia, Emergency department