Establishment of Reference Intervals for Selected Clinical Chemistry Parameters among Apparently Healthy Adults in Addis Ababa, Ethiopia
| dc.contributor.advisor | Tsegaye Aster | |
| dc.contributor.advisor | Kinde Samuel | |
| dc.contributor.author | Kassaw Melkitu | |
| dc.date.accessioned | 2020-12-16T12:09:37Z | |
| dc.date.accessioned | 2023-11-06T08:56:44Z | |
| dc.date.available | 2020-12-16T12:09:37Z | |
| dc.date.available | 2023-11-06T08:56:44Z | |
| dc.date.issued | 2020-06 | |
| dc.description.abstract | Background: Reference interval values are used as medical decision-making tools that are givenby clinical laboratory to assist health professionals, medical researchers for clinical trials and forphysician to diagnosis, treatment, and follow-up of patients.. Objective: This study aimed to establish reference interval for selected clinical chemistryparameters among apparently healthy adults living in Addis Ababa, Ethiopia. Method: community based cross sectional study was conducted from March to October 2019recruiting a total of 448 participants aged from 18-60 years. Medical history, physicalexamination, anthropometric and socio-demographic data were collected using structuredquestionnaire. Serum samples were analyzed for selected clinical chemistry parameters usingCobas 6000. Reference intervals were established by calculating 2.5th-97.5 percentile with90%Cl after excluding outliers using tukey method, Kolmogorov-Sminorv test. The differencebetween groups was computed using Mann-Whitney test by using SPSS version 23. P-value of<0.05 was taken as statistically significant. Result: In adults the reference interval of males and females were ALT 1.60-16.89U/l againstfemales 0.47-9.87U/l, AST 8.11-22.50 vs.6.95-18.05 U/l, ALP 44.0-181.65U/l; Albumin 4.405.88U/lvs.4.03-5.25U/l, T.protein 6.76-9.57g/l vs. 6.45-8.21g/l, T.bilirubin 0.26-1.15 vs.0.150.64mg/dl,D. bilirubin 0.08-0.46mg/dl vs. 0.061-0.25mg/dl, Glucose 62.93-99.39mg/dlvs.59.14-90.72mg/dl, Urea 13.21-33.51mg/dl vs.7.30-12.00mg/dl, Creatinine 0.56-1.02mg/dlvs.0.40-0.80mg/dl and Uric acid 3.41-7.40mg/dl, vs.1.88-5.60mg/dl, respectively. Statisticallysignificant differences were observed between males and females except Albumin and Totalproteins. Conclusion: the reference interval for selected clinical chemistry parameters of adults was lowerthan the values given by manufacturers and Africans studies. Hence, it is more useful usinglocally established reference interval than derived from other countries. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/24144 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Reference Interval, clinical chemistry | en_US |
| dc.title | Establishment of Reference Intervals for Selected Clinical Chemistry Parameters among Apparently Healthy Adults in Addis Ababa, Ethiopia | en_US |
| dc.type | Thesis | en_US |