Establishment of Reference Intervals for Selected Clinical Chemistry Parameters among Apparently Healthy Adults in Addis Ababa, Ethiopia
| dc.contributor.advisor | Tsegaye, Aster (MSc, PhD, Associate Professor) | |
| dc.contributor.advisor | Kinde, Samuel(MSc, PhD Candidate) | |
| dc.contributor.author | Kassaw, Melkitu | |
| dc.date.accessioned | 2020-12-16T12:09:37Z | |
| dc.date.accessioned | 2023-11-06T08:56:44Z | |
| dc.date.available | 2020-12-16T12:09:37Z | |
| dc.date.available | 2023-11-06T08:56:44Z | |
| dc.date.issued | 2020-06 | |
| dc.description.abstract | Background: Reference interval values are used as medical decision-making tools that are given by clinical laboratory to assist health professionals, medical researchers for clinical trials and for physician to diagnosis, treatment, and follow-up of patients.. Objective: This study aimed to establish reference interval for selected clinical chemistry parameters among apparently healthy adults living in Addis Ababa, Ethiopia. Method: community based cross sectional study was conducted from March to October 2019 recruiting a total of 448 participants aged from 18-60 years. Medical history, physical examination, anthropometric and socio-demographic data were collected using structured questionnaire. Serum samples were analyzed for selected clinical chemistry parameters using Cobas 6000. Reference intervals were established by calculating 2.5 th -97.5 percentile with 90%Cl after excluding outliers using tukey method, Kolmogorov-Sminorv test. The difference between groups was computed using Mann-Whitney test by using SPSS version 23. P-value of <0.05 was taken as statistically significant. Result: In adults the reference interval of males and females were ALT 1.60-16.89U/l against females 0.47-9.87U/l, AST 8.11-22.50 vs.6.95-18.05 U/l, ALP 44.0-181.65U/l; Albumin 4.405.88U/l vs.4.03-5.25U/l, T.protein 6.76-9.57g/l vs. 6.45-8.21g/l, T.bilirubin 0.26-1.15 vs.0.150.64mg/dl, D. bilirubin 0.08-0.46mg/dl vs. 0.061-0.25mg/dl, Glucose 62.93-99.39mg/dl vs.59.14-90.72mg/dl, Urea 13.21-33.51mg/dl vs.7.30-12.00mg/dl, Creatinine 0.56-1.02mg/dl vs.0.40-0.80mg/dl and Uric acid 3.41-7.40mg/dl, vs.1.88-5.60mg/dl, respectively. Statistically significant differences were observed between males and females except Albumin and Total proteins. Conclusion: the reference interval for selected clinical chemistry parameters of adults was lower than the values given by manufacturers and Africans studies. Hence, it is more useful using locally established reference interval than derived from other countries. th | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/24144 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Reference Interval, clinical chemistry | en_US |
| dc.title | Establishment of Reference Intervals for Selected Clinical Chemistry Parameters among Apparently Healthy Adults in Addis Ababa, Ethiopia | en_US |
| dc.type | Thesis | en_US |