Clinical and imaging characterization of patients with focal liver lesions with emphasis on hepatocellullar carcinoma at Tikur Anbessa Specialized Hospital (TASH) from august1, 2019to july30, 2020.
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Date
2020-12
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Addis Abeba University
Abstract
Abstract
Background: The accurate and reliable determination of the nature of the liver mass is
critical, not only to reassure individuals with benign lesions but also, and perhaps more
importantly, to ensure that malignant lesions are diagnosed correctly. Accurate diagnosis allows
the appropriate selection of optimal management.
Objective: This study was aimed to assess clinical and imaging characterization in patients
with focal liver lesions with emphasis on HCC at Tikur Anbessa specialized hospital (TASH)
from august1, 2019 to july30, 2020.
Method: Institution based descriptive and retrospective study was conducted from August 1,
2019 to July 30, 2020. A total of 135 patients with imaging result of focal liver lesion were
included in the study data was collected using standardized questionnaire. Clinical and imaging
pattern was assessed from records. Summary statistics like mean and median were computed.
Both bivariate and multivariate logistic regression was fitted to identify associated variables. A
95% confidence interval odds ratio (OR) was computed and considered variables having p -
value less than 0.05 in the multi variable model as significantly associated with the dependent
variables.
Result: A total of 135 patients were included in the study. The mean age was 49.83(SD 13.866)
years. Most of the patients were from Addis Ababa and Oromia (82.3%). Majority of lesions in
this study were malignant (81%), hepatocellular carcinoma (63%) and hemangioma (29.9%)
being the commonest malignant and benign lesions respectively. Many of the lesions were
solitary (62%) and size ≥5cm. right lobe was mostly involved (57.1%). Abdominal pain was the
commonest presentation (74.8%) in most of the patient. HBV (22.2%) and HCV(7.4%) infection
was significantly associated with hepatocellular carcinoma among the risk factors.
Conclusion: Majority of lesions in this study were malignant and solitary. Hepatocellular
carcinoma and hemangioma were commonest malignant and benign lesions respectively. Right
lobe was mostly involved and abdominal pain was the commonest presentation in most of the
patient. Among the risk factors HBV and HCV infection was significantly associated with
hepatocellular carcinoma.
Grant source: Addis Ababa University, college of health sciences, school of medicine
Description
Keywords
Clinical, imaging, characterization, focal liver lesions, Ethiopia.