Prevalence of Anxiety and Depression symptoms among patients with Inflammatory Bowel Disease: A Multicenter Study
| dc.contributor.advisor | Adem,Ahmed (MD) | |
| dc.contributor.advisor | Limenhe, Asnake(MD) | |
| dc.contributor.author | Sugie,Mohammed Momin | |
| dc.date.accessioned | 2025-08-12T20:01:31Z | |
| dc.date.available | 2025-08-12T20:01:31Z | |
| dc.date.issued | 2024-03 | |
| dc.description.abstract | Background: Global evidences have observed that individuals with Inflammatory Bowel Disease (IBD) are at a heightened risk of experiencing psychiatric disorders, which often coincide with a decrease in their quality of life Objective: To assess the prevalence of anxiety and depression symptoms and associated factors among patients with Inflammatory Bowel Disease at Tikur Anbessa Specialized Hospital and Adera Medical Center, Addis Ababa, Ethiopia from June to September, 2023 Methods: Institutional based cross-sectional study was conducted at Tikur Anbesa Specialized Hospital and Adera Medical Center. Simple random sampling was used to select 118 patients. The categorical variables in the study were presented using frequency and percentage, and compared between groups using the chi-square test. The normal distribution of the continuous variables was assessed using Shapiro-ilk test. The mean and standard deviation was calculated for normality distributed data while median and interquartile range calculated for skewed data. A univariate and multivariate binary logistic regression analysis was performed to examine the factors associated with Depression and Anxiety symptoms in IBD patients. The results of logistic regression were reported as adjusted odds rations (OR) with 95% confidence intervals and p-value < 0.05 considered statistically significant. Results: An analysis of 118 patients was conducted, revealing a median age of 33 years with an interquartile range of 12.5 years. Among the participants, 67.8% were female, and 53.4% were employed. The study revealed a 5.1% prevalence of anxiety symptoms and 7.1% prevalence of depressive symptoms among individuals with IBD. After adjusting for multiple variables in the multivariate analysis, it was found that moderate disease activity (AOR=16.1(1.7,156.7), p=0.015) and severe disease activity (AOR=49.8(2.1,1144.02), p=0.014) had a statistically significant association with increased rates of depressive symptoms in IBD patients. However, smokers (AOR=1.6(0.15,17.22), p=0.053) and those with a disease duration of less than 4 years (AOR=1.6(0.49, 17.2), p=0.07) also showed a positive association with the development of significant depressive symptoms, though these associations did not reach statistical significance. In addition, the study ascertained that moderate disease activity (AOR=9.9, 95% CI: 0.9, 106.2, p=0.058) had positive association while severe disease activity (AOR=45.3, 95%CI: 2.0, 1018.0, p=0.016) emerged as a statistically significant associated factor with having anxiety symptoms. Conclusion: The prevalence of anxiety and depressive symptoms in this study were generally low, but can increase due to important factors such as disease activity, smoking, unemployment, a short duration after diagnosis, and having ulcerative IBD | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/6495 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Anxiety | |
| dc.subject | Depression symptoms | |
| dc.subject | Patients | |
| dc.subject | Inflammatory Bowel Disease | |
| dc.title | Prevalence of Anxiety and Depression symptoms among patients with Inflammatory Bowel Disease: A Multicenter Study | |
| dc.type | Thesis |