Establishment of serum lipid profile and electrolytes reference intervals for apparently healthy children and adolescents in Addis Ababa, Ethiopia
| dc.contributor.advisor | Wolde, Mistire(BSc, MSc, PhD Associate professor) | |
| dc.contributor.advisor | Tsegaye, Aster(MSc, PhD Associate professor) | |
| dc.contributor.author | Mohammed, Ousman | |
| dc.date.accessioned | 2020-12-22T07:38:35Z | |
| dc.date.accessioned | 2023-11-06T08:56:37Z | |
| dc.date.available | 2020-12-22T07:38:35Z | |
| dc.date.available | 2023-11-06T08:56:37Z | |
| dc.date.issued | 2020-07 | |
| dc.description.abstract | Background: Reliable and accurate reference intervals for laboratory analyses are an integral part of correct interpretation of clinical laboratory test results. In Addis Ababa, Ethiopia, there were no reference intervals established on lipid profile and electrolytes which are essential in the assessment of early dyslipidemia and electrolyte abnormalities. Objective: To establish reference intervals on serum lipid profile and electrolytes for apparently healthy children and adolescents from April to October 2019 in Addis Ababa, Ethiopia. Methods: Community based cross sectional study was conducted from April to October 2019. A total of 522 participants aged 5-17 years were recruited from communities. After physical examination, socio-demographic, anthropometric data and blood samples were collected. Serum levels of lipid profile and electrolytes were determined using Cobas c501. In accordance with Clinical and Laboratory Standards Institute guidelines reference intervals for four lipid profile and six electrolytes were established by calculating 2.5 th and 97.5 th limits with 90% confidence interval using SPSS version 23. Results: In children, the reference intervals for serum potassium, sodium, chloride, calcium, magnesium and phosphate in mmol/L were 4.37-5.2, 137-145.5, 101.9-107.9, 2.34-2.7, 0.74-0.97, and 1.42-1.85 and for total cholesterol, triglycerides, low density lipoprotein and high density lipoprotein the respective values were 100.76-171.7, 44.16-126.36, 60.6-105.6 and 31.6-53.7 in mg/dl, for both sexes. For adolescents 4.03-5.58, 137-146, 98.9-120.9, 2.39-2.7, 0.73-0.96, 0.961.8 for serum potassium, sodium, chloride, calcium, magnesium, phosphate in mmol/L and 97.2189.1, 40.5-143.6, 41.7-120.9 and 21.3-57 in mg/dl for total cholesterol, triglycerides, low density lipoprotein and high density lipoprotein, respectively, for both sexes. Conclusion: The obtained reference intervals by the current study revealed that both lower and upper limits were in disagreement with the manufacture as well as published literatures. The study also observed significant differences in the reference values between genders for all analytes except sodium, calcium and magnesium at the adolescents. Therefore, it is important to use the current reference intervals. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/24256 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Reference intervals, lipid profile, electrolyte, children and adolescent | en_US |
| dc.title | Establishment of serum lipid profile and electrolytes reference intervals for apparently healthy children and adolescents in Addis Ababa, Ethiopia | en_US |
| dc.type | Thesis | en_US |