Incidence of adverse effects and associated factors after intrathecal administration of morphine in elective surgeries in Tikur Anbessa specialized Hospital, Addis Ababa, Ethiopia, 2024,GC.
| dc.contributor.advisor | Abebe,Yonathan (MD, Ass.Prof.) | |
| dc.contributor.advisor | Shamil,Amria (MD, Ass.Prof.) | |
| dc.contributor.author | Niftalem, Firaol | |
| dc.date.accessioned | 2025-08-13T07:33:24Z | |
| dc.date.available | 2025-08-13T07:33:24Z | |
| dc.date.issued | 2024-05 | |
| dc.description.abstract | Background:One of the most efficient analgesic techniques in various surgical operations is the intraspinal injection of opioids (1,2). Intrathecal morphine can enhance and prolong intraoperative and postoperative analgesia when used alone or in conjunction with a local anesthetic. However, a wide range of clinically significant adverse effects have been documented. This covers symptoms including nausea, vomiting, pruritus, urine retention, or respiratory depression(1,3). Objectives:Determining the incidence of adverse effects and associated factors after intrathecal administration of morphine in elective surgeries. Methods:A cross-sectional analytic study was conducted on patients who underwent elective surgery with spinal anesthesia combined with morphine at Tikur Anbessa Specialized Hospital. The data was collected within 24 hours after the administration of intrathecal morphine. The study used the binary and logistic regression models to assess the association between morphine- related adverse effects and potential independent factors. Result:Among 273 study participants who received spinal anesthesia combined with intrathecal morphine, 78(28.6%) and 42(15%) had nausea and vomiting respectively. And 63(23.1%) of the participants reported having pruritus, 11(4%) reported urinary retention and respiratory depression was reported as shortness of breath 10(3.7%) and cyanosis/respiratory rate less than 10 (2.7%) in the study. Conclusion and Recomendation:A study was conducted to determine the adverse effects of intrathecal morphine and associated factors in elective patients. The findings revealed that a considerable proportion of participants experienced nausea, vomiting, pruritus, urinary retention, and respiratory depression. Vigilant monitoring and tailored interventions are needed to mitigate the risk of adverse effects. Further research is warranted to optimize patient outcomes. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/6592 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Analgesic techniques | |
| dc.subject | Surgical operations | |
| dc.title | Incidence of adverse effects and associated factors after intrathecal administration of morphine in elective surgeries in Tikur Anbessa specialized Hospital, Addis Ababa, Ethiopia, 2024,GC. | |
| dc.type | Thesis |