Incidence of adverse effects and associated factors after intrathecal administration of morphine in elective surgeries in Tikur Anbessa specialized Hospital, Addis Ababa, Ethiopia, 2024,GC.
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Date
2024-05
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Addis Ababa University
Abstract
Background:One of the most efficient analgesic techniques in various surgical operations is the intraspinal
injection of opioids (1,2). Intrathecal morphine can enhance and prolong intraoperative and
postoperative analgesia when used alone or in conjunction with a local anesthetic. However, a
wide range of clinically significant adverse effects have been documented. This covers
symptoms including nausea, vomiting, pruritus, urine retention, or respiratory depression(1,3).
Objectives:Determining the incidence of adverse effects and associated factors after intrathecal
administration of morphine in elective surgeries.
Methods:A cross-sectional analytic study was conducted on patients who underwent elective surgery
with spinal anesthesia combined with morphine at Tikur Anbessa Specialized Hospital. The
data was collected within 24 hours after the administration of intrathecal morphine. The study
used the binary and logistic regression models to assess the association between morphine-
related adverse effects and potential independent factors.
Result:Among 273 study participants who received spinal anesthesia combined with intrathecal
morphine, 78(28.6%) and 42(15%) had nausea and vomiting respectively. And 63(23.1%) of
the participants reported having pruritus, 11(4%) reported urinary retention and respiratory
depression was reported as shortness of breath 10(3.7%) and cyanosis/respiratory rate less than
10 (2.7%) in the study.
Conclusion and Recomendation:A study was conducted to determine the adverse effects of intrathecal morphine and associated
factors in elective patients. The findings revealed that a considerable proportion of participants
experienced nausea, vomiting, pruritus, urinary retention, and respiratory depression. Vigilant
monitoring and tailored interventions are needed to mitigate the risk of adverse effects. Further
research is warranted to optimize patient outcomes.
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Keywords
Analgesic techniques, Surgical operations