Prevalence and Antimicrobial Susceptibility of Entrococcus Species Isolated from Different Clinical Samples at Tikur Anbesa Hospital Addis Ababa, Ethiopia
| dc.contributor.advisor | Desta, Kassu (Assistant Professor) | |
| dc.contributor.author | Tena, Zelalem | |
| dc.date.accessioned | 2018-07-03T14:22:55Z | |
| dc.date.accessioned | 2023-11-06T08:56:16Z | |
| dc.date.available | 2018-07-03T14:22:55Z | |
| dc.date.available | 2023-11-06T08:56:16Z | |
| dc.date.issued | 2016-05 | |
| dc.description.abstract | Background: Enterococci which are part of the normal intestinal flora are opportunistic human pathogens. The two most important species, E.faecalis and E.faecium are among the leading causes of nosocomial infections that may cause severe infections including endocarditis, urinary tract infection, septicemia and wound infections which are often difficult to treat. Their increasing importance is largely due to their resistance to antimicrobials. So the aim this study is to determine the prevalence and antimicrobial pattern of Entrococcus spp. Objective: To determine the prevalence and antimicrobial susceptibility of Entrococcus species isolated from different clinical samples at Tikur Anbesa Specialized Hospital Addis Ababa, Ethiopia . Method: A cross sectional study was conducted from April to May 2016 on patients visiting Tikur Anbesa Specialized Hospital. A total of 422 patients were included in the study. Clinical samples(blood, urine, pus, bodyfluid and csf) was inoculated onto blood agar and mackonky culture media .The isolates were identified by cultural characteristics, Gram’s stain, catalase test, growth in 6.5% NaCl broth, bilesculin test, PYR test. Drug susceptibility pattern of the isolates were determined using the Kirby Bauer disc diffusion method. Confirmation of vancomycin susceptibility was done by the Epsilometer test to determine the Minimum Inhibitory Concentration. Results obtained from the study was entered to excel spreadsheet and transport to and analyzed using SPSS version 20 to test for statistical associations. P values less than 0.05 were considered as significant. Result:From a total of 422 sample processed 15 Entrococcus spp were isolated .Among the isolate 53.3% were female and 46.7 %were male patients . In this studyLizolide were the drug of choice for Entrococcus spp 100% sensitive followed by Vancomycen 93.3% sensitive in contrast Ampcillen was highly resistance by 80% followed by Doxicyclin 73.3% resistance. Conclusion: This study showed that the rate of isolated Enterococci was 3.5% and had variable degrees of resistance to the antibiotics, but all were sensitive to Linzolide by disc diffusion methods so the presence of VREand multidrug resistant Enterococci in our study should be considered as an alarm for serious Enterococcal infections . Key words: Entrococcus, Nosocomial infection, clinical samples , Antibiotic susceptibility | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/6052 | |
| dc.language.iso | en | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | Entrococcus | en_US |
| dc.subject | Nosocomial infection | en_US |
| dc.subject | Clinical samples | en_US |
| dc.title | Prevalence and Antimicrobial Susceptibility of Entrococcus Species Isolated from Different Clinical Samples at Tikur Anbesa Hospital Addis Ababa, Ethiopia | en_US |
| dc.type | Thesis | en_US |