Magnitude of Hepatitis B Virus, Hepatitis C Virus and HIV among Febrile Patients Attending Health Institute at Aura District, Afar Region, Ethiopia
| dc.contributor.advisor | Desta Kasu | |
| dc.contributor.advisor | Zerfu Biruk | |
| dc.contributor.author | Edao Rago | |
| dc.date.accessioned | 2021-12-31T06:07:44Z | |
| dc.date.accessioned | 2023-11-06T08:57:11Z | |
| dc.date.available | 2021-12-31T06:07:44Z | |
| dc.date.available | 2023-11-06T08:57:11Z | |
| dc.date.issued | 2021-07 | |
| dc.description.abstract | Background: Hepatitis B, Hepatitis C, and HIV are among the major public health concernsglobally and are highly infectious diseases. During the first six months, most of the infectionswith viral hepatitis are often asymptomatic; therefore, detection of the virus at the early stageis difficult. The burden of viral hepatitis B and hepatitis C infections and co-infection withHIV still underreported in Ethiopia due to the lack of a coordinated health system and datamanagement inability at the central level. In spite of increasing studies on viral hepatitis andtheir co-morbidity at different parts of the country, few data exists in Awra and Gulinadistrict of Afar region. Objective: To assess the burden of hepatitis B & C viruses and HIV among patientsattending health facilities and association of viruses with socio-demographic factors and eachother virus. Method: A cross-sectional study was performed among 400 sera that were collected fromKelewani primary hospital and Derayitu health centre of Awra and Gulina district of AfarRegion, north-eastern part of Ethiopia from February to May 2019. A pilot study wereperformed to assess the positive rate of both HCV, HBV and HIV to proceed with theresearch and continuous monitoring of the refrigerator was checked during the last couple ofmonths to assure sample storage and stability before analysis. The two hepatitis viruses werescreened by Anti-HCV and HBsAg rapid test kits, the seropositive sera were subjected toELISA. HIV was screened sequentially by following HIV rapid test algorithm of Ethiopia;positive sera were confirmed by ELISA. Data were entered, coded and analyzed using SPSSstatistical software version 25. A p-value < than 0.05 was considered statistically significant, Result: A total of 400 sera (59.8% of female) of age ranging from 4-80 years (mean= 25.9,SD = ±11.6) were used for this study. Of all samples 13% (52/400), were sero-positive forone or two viruses, specifically 9.8 %( 39/400), 1% (4/400) and 2.3% (9/400) for HBV, HCVand HIV respectively. 0.5% (2/400) was corresponded to the co-infections of HCV-HBV andHBV-HIV. The rates of positivity among both sexes were relatively similar; from the groupHBV, HCV and HIV respectively. HIV was more common in age category of 30 years andabove (COR=7.536, 95% CI=1.543-36.803, p-value = 0.013). Conclusion: The burden of HBV and HIV at this study area were found high among febrilepatients. Similarly, HIV was significantly distributed among elderly febrile patients that maybe an indication for these contagious viruses to be circulated in the community. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/29443 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Hepatitis B virus, hepatitis C virus , HIV | en_US |
| dc.title | Magnitude of Hepatitis B Virus, Hepatitis C Virus and HIV among Febrile Patients Attending Health Institute at Aura District, Afar Region, Ethiopia | en_US |
| dc.type | Thesis | en_US |