Hepatitis B and Hepatitis C Viral Infections And Their Associated Factors Among Diabetes Patients Attending University of Gondar Referral Teaching Hospital, Northwest Ethiopia
| dc.contributor.advisor | Desta, Kassu (Assistant Professor) | |
| dc.contributor.author | Million, Yihenew | |
| dc.date.accessioned | 2018-07-03T14:13:04Z | |
| dc.date.accessioned | 2023-11-06T08:56:16Z | |
| dc.date.available | 2018-07-03T14:13:04Z | |
| dc.date.available | 2023-11-06T08:56:16Z | |
| dc.date.issued | 2017-06 | |
| dc.description.abstract | Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses whose primary replication occurs in the liver. A range of extrahepatic manifestations such as arthralgias, thyroiditis and diabetes are linked with HCV infections. Patients with diabetes mellitus are predisposed to develop a spectrum of liver diseases. Objective: To determine the burden of Hepatitis B and Hepatitis C virus and their associated Factors among diabetes patients attending University of Gondar Referral Teaching Hospital, Northwest Ethiopia. Methods: A comparative cross sectional study design was employed on 305 diabetes and 305 diabetes free individuals from October 2016 to February 2017. Pre-tested structured interviewer based questionnaire was used to collect data. Blood specimen was collected and serum was separated to determine hepatitis B surface antigen (HBsAg) and anti-HCV by Enzyme linked immunosorbent Assay (ELISA) assay. Data were entered with epidata; then exported to, cleared and analyzed by the statistical software SPSS version 20. Univariable and multivariable logistic regression analyses were performed to identify factors that contribute to the occurrence of Hepatitis B and Hepatitis C viral infections. Statistical significance was considered whenever p- value was less than 0.05. Result: Out of the total, 10.7% was found to be positive for Hepatitis infections, of which 14.43 % and 6.89% study participants were sero-positive for at least one of the viruses in diabetes and control groups respectively. The sero-positivity of Hepatitis B was 8.5% and 4.6% (95% CI, 0.96 - 4.02); and Hepatitis C viral infections 7.5% and 2.3% (95%CI, 1.46 - 8.68) in diabetes and control groups respectively. History of blood transfusion (95% CI, 1.36 - 12.71) and unprotected sex (95% CI, 1.25 - 10.15) were found to be significantly associated with HBsAg sero-positivity and type of diabetes (95% CI, 1.25 - 10.89) was independently associated with anti-HCV seropositivity. Conclusion and recommendation: Even though no statistically significant difference detected in HBV infection, the sero-positivity against anti- HCV antibody in diabetes and controls groups was found to be 7.5% and 2.3%, respectively and the difference was statistically significant (p-value< 0.001). Prospective studies are needed to confirm temporal association and elucidate the reasons of association between DM and Hepatitis B and C viruses. Key words፡ HBV, HCV, DM, Coinfection, University of Gondar Referral Teaching Hospital | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/6049 | |
| dc.language.iso | en | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | HBV | en_US |
| dc.subject | HCV | en_US |
| dc.subject | DM | en_US |
| dc.subject | Coinfection | en_US |
| dc.subject | University of Gondar Referral Teaching Hospital | en_US |
| dc.title | Hepatitis B and Hepatitis C Viral Infections And Their Associated Factors Among Diabetes Patients Attending University of Gondar Referral Teaching Hospital, Northwest Ethiopia | en_US |
| dc.type | Thesis | en_US |