Hepatitis B and Hepatitis C Viral Infections And Their Associated Factors Among Diabetes Patients Attending University of Gondar Referral Teaching Hospital, Northwest Ethiopia
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Date
2017-06
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Addis Ababa University
Abstract
Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses whose
primary replication occurs in the liver. A range of extrahepatic manifestations such as arthralgias,
thyroiditis and diabetes are linked with HCV infections. Patients with diabetes mellitus are
predisposed to develop a spectrum of liver diseases.
Objective: To determine the burden of Hepatitis B and Hepatitis C virus and their associated
Factors among diabetes patients attending University of Gondar Referral Teaching Hospital,
Northwest Ethiopia.
Methods: A comparative cross sectional study design was employed on 305 diabetes and 305
diabetes free individuals from October 2016 to February 2017. Pre-tested structured interviewer
based questionnaire was used to collect data. Blood specimen was collected and serum was
separated to determine hepatitis B surface antigen (HBsAg) and anti-HCV by Enzyme linked
immunosorbent Assay (ELISA) assay. Data were entered with epidata; then exported to, cleared
and analyzed by the statistical software SPSS version 20. Univariable and multivariable logistic
regression analyses were performed to identify factors that contribute to the occurrence of
Hepatitis B and Hepatitis C viral infections. Statistical significance was considered whenever p-
value was less than 0.05.
Result: Out of the total, 10.7% was found to be positive for Hepatitis infections, of which 14.43
% and 6.89% study participants were sero-positive for at least one of the viruses in diabetes and
control groups respectively. The sero-positivity of Hepatitis B was 8.5% and 4.6% (95% CI, 0.96
- 4.02); and Hepatitis C viral infections 7.5% and 2.3% (95%CI, 1.46 - 8.68) in diabetes and control
groups respectively. History of blood transfusion (95% CI, 1.36 - 12.71) and unprotected sex (95%
CI, 1.25 - 10.15) were found to be significantly associated with HBsAg sero-positivity and type of
diabetes (95% CI, 1.25 - 10.89) was independently associated with anti-HCV seropositivity.
Conclusion and recommendation: Even though no statistically significant difference detected in
HBV infection, the sero-positivity against anti- HCV antibody in diabetes and controls groups was
found to be 7.5% and 2.3%, respectively and the difference was statistically significant (p-value<
0.001). Prospective studies are needed to confirm temporal association and elucidate the reasons
of association between DM and Hepatitis B and C viruses.
Key words፡ HBV, HCV, DM, Coinfection, University of Gondar Referral Teaching Hospital
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Keywords
HBV, HCV, DM, Coinfection, University of Gondar Referral Teaching Hospital