Hematological Parameters of Patients with Thyroid Dysfunction at S.t Paul‟s Hospital Millennium Medical College, Addis Ababa, Ethiopia
| dc.contributor.advisor | Negash Mikyas | |
| dc.contributor.advisor | Tibebu Melatwork | |
| dc.contributor.author | Mohammed Kedir | |
| dc.date.accessioned | 2021-05-30T07:01:28Z | |
| dc.date.accessioned | 2023-11-06T08:56:25Z | |
| dc.date.available | 2021-05-30T07:01:28Z | |
| dc.date.available | 2023-11-06T08:56:25Z | |
| dc.date.issued | 2021-03 | |
| dc.description.abstract | Background: Thyroid hormones have a decisive role in metabolism and proliferation of bloodcells and blood cells indices. Thyroid dysfunction leads different effects on blood cells such asanemia, leukopenia, thrombocytopenia, and in rare cases causes pancytopenia. Objectives: To determine hematological parameters of patients with thyroid dysfunction at S.tPaul‟s Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia, from March-August, 2020. Methods: A hospital based comparative cross sectional study was conducted from March toAugust, 2020, at SPHMMC, Addis, Ababa, Ethiopia. Convenient sampling technique was usedfor comprising of a total of 180. Participants‟ socio-demographic and clinical information wascollected from hospital cards. Initially 10 ml of venous blood samples were collected in to twoseparated test tubes. The blood specimen in the plain tube used for measurement of TSH, T3 andT4 (Cobase e 411 immunoassay system). Sample in the EDTA tubes, used for CBC analysis(Beckman-coulter hematology analyzer). Descriptive statistics was used to express the sociodemographic and clinical characteristics. Independent T test to compare mean value between thegroups, binary and multiple logistic regressions were computed to assess association be-tweenvariables using SPSS version 20. P value less than 0.05 were taken as statistical significant. Results: Of the 180 study participants, 74(41.1%) hypothyroidism and 49(27.2) hyperthyroidismand 57(31.8%) were apparently healthy controls. Of them 137 (71.1 %) were female, most in theage group 26-39 years (84, 46.7%). The result obtained showed a statistically significantdecrease in RBC count, Hb, HCT, MCV, PLT counts and MPV in thyroid dysfunction patients when compared with apparently healthy controls (p value <0.05). MCHC, RDW, WBC andNEU% were statistically significant increased (p value <0.05). MCH, MON%, EOS% andBAS%, did not showed significant difference between the groups (p value >0.05). Conclusion: Thyroid hormones have a significant influence on blood cell count and blood cellindices. This study showed that statistical significant difference in RBCs, Hb, HCT, MCVMCHC, total WBC count, neutrophils, PLT count, and MPV between patients with thyroid dysfunction and apparently healthy controls (p<0.05). But no difference showed MCH,monocytes, eosinophil and basophils between those groups (p- value > 0.05). | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/26586 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Blood cell count, Blood cell indices, Hypothyroidism, Hyperthyroid | en_US |
| dc.title | Hematological Parameters of Patients with Thyroid Dysfunction at S.t Paul‟s Hospital Millennium Medical College, Addis Ababa, Ethiopia | en_US |
| dc.type | Thesis | en_US |