Hematological Parameters of Patients with Thyroid Dysfunction at S.t Paul‟s Hospital Millennium Medical College, Addis Ababa, Ethiopia
No Thumbnail Available
Date
2021-03
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba University
Abstract
Background: Thyroid hormones have a decisive role in metabolism and proliferation of blood
cells and blood cells indices. Thyroid dysfunction leads different effects on blood cells such as
anemia, leukopenia, thrombocytopenia, and in rare cases causes pancytopenia.
Objectives: To determine hematological parameters of patients with thyroid dysfunction at S.t
Paul‟s Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia, from March-
August, 2020.
Methods: A hospital based comparative cross sectional study was conducted from March to
August, 2020, at SPHMMC, Addis, Ababa, Ethiopia. Convenient sampling technique was used
for comprising of a total of 180. Participants‟ socio-demographic and clinical information was
collected from hospital cards. Initially 10 ml of venous blood samples were collected in to two
separated test tubes. The blood specimen in the plain tube used for measurement of TSH, T3 and
T4 (Cobase e 411 immunoassay system). Sample in the EDTA tubes, used for CBC analysis
(Beckman-coulter hematology analyzer). Descriptive statistics was used to express the socio
demographic and clinical characteristics. Independent T test to compare mean value between the
groups, binary and multiple logistic regressions were computed to assess association be-tween
variables using SPSS version 20. P value less than 0.05 were taken as statistical significant.
Results: Of the 180 study participants, 74(41.1%) hypothyroidism and 49(27.2) hyperthyroidism
and 57(31.8%) were apparently healthy controls. Of them 137 (71.1 %) were female, most in the
age group 26-39 years (84, 46.7%). The result obtained showed a statistically significant
decrease in RBC count, Hb, HCT, MCV, PLT counts and MPV in thyroid dysfunction patients
when compared with apparently healthy controls (p value <0.05). MCHC, RDW, WBC and
NEU% were statistically significant increased (p value <0.05). MCH, MON%, EOS% and
BAS%, did not showed significant difference between the groups (p value >0.05).
Conclusion: Thyroid hormones have a significant influence on blood cell count and blood cell
indices. This study showed that statistical significant difference in RBCs, Hb, HCT, MCV
MCHC, total WBC count, neutrophils, PLT count, and MPV between patients with thyroid
dysfunction and apparently healthy controls (p<0.05). But no difference showed MCH,
monocytes, eosinophil and basophils between those groups (p- value > 0.05).
Description
Keywords
Blood cell count, Blood cell indices, Hypothyroidism, Hyperthyroid