Evaluation of Hematological Profiles among Helicobacter Pylori Infected Adult Outpatients at Wolkite Health Center, Guraghe Zone, Southern Ethiopia
| dc.contributor.advisor | Tsegaye Aster | |
| dc.contributor.advisor | Tibebu Melatwork | |
| dc.contributor.author | Moshago Yemeserach | |
| dc.date.accessioned | 2024-11-28T09:52:47Z | |
| dc.date.available | 2024-11-28T09:52:47Z | |
| dc.date.issued | 2023-06 | |
| dc.description.abstract | Background: Helicobacter pylori (H. pylori) infection is the most prevalent gastrointestinalbacterial disease which can disturb hematological parameters of the host and results diversecomplications such as anemia,thrombocytopenia and gastric lymphoma. Objective: This study aimed to evaluate Hematological Profiles among Helicobacter pyloriinfected adult outpatients at Wolkite Health Center, from Jan-April 2023. Methods: This study employed a comparative cross-sectional study design to recruit 340(170each with age and sex matched) adult outpatients with and without Helicobacter pylori infection.Socio-demographic data was collected using questionnaire. A stool sample was obtained andexamined for intestinal parasites and the H. pylori antigen. Blood was collected and analyzed forfull blood count, using mindray BC 3000plus hematological analyzer and for screening hemo-parasites at wolkite health center laboratory. The entry and analysis of quantitative data weredone using mean and standard deviation and were processed using SPSS version 22. Differencesin mean values of hematological parameters between H. pylori positive and negative subjectswere tested by independent sample T-test, at 95% confidence interval. Results: Among 170 H. pylori infected adult outpatients 54% were females. The mean HGB(13.56±1.59 g/dl vs.14.01±1.33g/dl, p=0.005), hematocrit (40.98 ±4.81% vs 41.75±3.79%,p=0.029) and leukocytes (6.86 ±2.84 x109/l vs. 6.94±1.77 x109/l, p=0.003) were significantlydecreased while percentage of lymphocyte was increased (31.89 ±11.29%vs. 29.56 ±8.60%,p<0.001), the mean difference count for platelets (242.62 ±68.82 x109/l vs 267.46 ±54.71x109/l, p=0.054)was at the border of significant in Helicobacter pylori infected patientscomparing with uninfected groups. Seventeen (10%) of the H. pylori infected patients werepositive for intestinal parasites. However, only the MID population was significantly higher inthe co-infected group, compared to H. pylori only infected patients (9.73 ±4.45 vs 9.64 ±3.00,p=0.021). Anemia was observed in 27/170 (15.8%) H. pylori positive patients (6 males and 21females), 12/170(7.1%) and 20/170(11.8%) thrombocytopenia and leukopenia were observed inpositive subjects respectively. Conclusion: H. pylori can affect some hematological profiles of adult patients. Performinghematological test for H. pylori infected patients is recommended to manage this illness andfurther complications. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/3738 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Helicobacter pylori hematological profiles intestinal parasites | |
| dc.title | Evaluation of Hematological Profiles among Helicobacter Pylori Infected Adult Outpatients at Wolkite Health Center, Guraghe Zone, Southern Ethiopia | |
| dc.type | Thesis |