Evaluation of Hematological Profiles among Helicobacter Pylori Infected Adult Outpatients at Wolkite Health Center, Guraghe Zone, Southern Ethiopia
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Date
2023-06
Authors
Moshago,Yemeserach
Journal Title
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Publisher
Addis Ababa University
Abstract
Background: Helicobacter pylori (H. pylori) infection is the most prevalent gastrointestinal
bacterial disease which can disturb hematological parameters of the host and results diverse
complications such as anemia, thrombocytopenia and gastric lymphoma.
Objective: This study aimed to evaluate Hematological Profiles among Helicobacter pylori
infected adult outpatients at Wolkite Health Center, from Jan-April 2023.
Methods: This study employed a comparative cross-sectional study design to recruit 340(170
each with age and sex matched) adult outpatients with and without Helicobacter pylori infection.
Socio-demographic data was collected using questionnaire. A stool sample was obtained and
examined for intestinal parasites and the H. pylori antigen. Blood was collected and analyzed for
full blood count, using mindray BC 3000plus hematological analyzer and for screening hemo-
parasites at wolkite health center laboratory. The entry and analysis of quantitative data were
done using mean and standard deviation and were processed using SPSS version 22. Differences
in mean values of hematological parameters between H. pylori positive and negative subjects
were tested by independent sample T-test, at 95% confidence interval.
Results: Among 170 H. pylori infected adult outpatients 54% were females. The mean HGB
(13.56±1.59 g/dl vs.14.01±1.33g/dl, p=0.005), hematocrit (40.98 ±4.81% vs 41.75±3.79%,
p=0.029) and leukocytes (6.86 ±2.84 x109/l vs. 6.94±1.77 x109/l, p=0.003) were significantly
decreased while percentage of lymphocyte was increased (31.89 ±11.29%vs. 29.56 ±8.60%,
p<0.001), the mean difference count for platelets (242.62 ±68.82 x109/l vs 267.46 ±54.71
x109/l, p=0.054)was at the border of significant in Helicobacter pylori infected patients
comparing with uninfected groups. Seventeen (10%) of the H. pylori infected patients were
positive for intestinal parasites. However, only the MID population was significantly higher in
the co-infected group, compared to H. pylori only infected patients (9.73 ±4.45 vs 9.64 ±3.00,
p=0.021). Anemia was observed in 27/170 (15.8%) H. pylori positive patients (6 males and 21
females), 12/170(7.1%) and 20/170(11.8%) thrombocytopenia and leukopenia were observed in
positive subjects respectively.
Conclusion: H. pylori can affect some hematological profiles of adult patients. Performing
hematological test for H. pylori infected patients is recommended to manage this illness and
further complications.
Description
Keywords
Helicobacter pylori, hematological profiles, intestinal parasites