Synthesis, In Vitro Antimicrobial, and In Silico Analysis of Camphor-Based Schiff Base Derivative
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Date
2025-12-10
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Addis Ababa University
Abstract
Microbial diseases are among the leading causes of mortality and morbidity worldwide. The rise
of antimicrobial resistance has become a significant challenge, as microorganisms have
developed resistance to many existing drugs. Therefore, the search for new antimicrobials is
critically important. Schiff bases (SB) and their derivatives exhibit a wide range of biological
activities, including antimicrobial, anti-inflammatory, antimalarial, anticancer, and antioxidant
effects, among others. Camphor (1) is a terpenoid (1, 7, 7-trimethylbicyclo [2.2.1]-2-heptanone),
exists in two enantiomeric forms (1S)-m (-) is a synthetic camphor and (1R)-(+) is a natural
camphor.
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Keywords
R-camphor, Schiff bases, synthesis, antimicrobial activity, molecular docking, ADMET