Assessment of Selected Clinical Chemistry Test Alterations and Associated Risk Factors among Visceral Leishmaniasis Patients Attending at Kahsay Abera and Mearg Hospitals Western Tigrai, Northern Ethiopia, 2019: a Comperative Study
| dc.contributor.advisor | Wolde Mistire | |
| dc.contributor.advisor | Tsegaye Aster | |
| dc.contributor.author | Tesfanchal Brhane | |
| dc.date.accessioned | 2020-05-21T13:26:55Z | |
| dc.date.accessioned | 2023-11-06T08:56:32Z | |
| dc.date.available | 2020-05-21T13:26:55Z | |
| dc.date.available | 2023-11-06T08:56:32Z | |
| dc.date.issued | 2019-06 | |
| dc.description.abstract | Introduction: Visceral leishmaniasis causes alterations of lipid metabolism and associated withhypochlesterolemia and severe hypertriglyceridemia. Hepatic dysfunction and life threatinghepatitis is associated with visceral leishmaniasis. Kidney damage is frequently associated withincreased morbidity and mortality in visceral leishmaniasis patients. However there is nopublished data on the effect of visceral leishmaniasis to kidney, liver, and lipid profiles inEthiopia particularly in the study area. Objective: To assess selected clinical chemistry test alterations and associated risk factors among visceral leishmaniasis patients attending at Kahsay Abera and Mearg Hospitals WesternTigrai, Northern Ethiopia from November 2018 -March 2019. Method: Institutional based comparative cross sectional study was conducted from November2018 to March 2019 in Kahsay Abera and Mearg Hospitals, Western Tigrai, Northern Ethiopia.A total of 100 visceral leishmaniasis patients and 100 control groups working in Kahsay Aberaand Mearg Hospitals without visceral leishmaniasis were selected by using convenient samplingtechniques. The samples were processed and analysed by Mindray 200E automated clinicalchemistry analyzer. Data was entered and analyzed using SPSS Version 23. Descrpptivesatatisticss, independent-test, binary logistic regressions were used for data analysis. P values <0.05 were considerd as statistically significant at 95% confidence level. Result: From 100 visceral leishmaniasis 9(9%), 10 (10%), 15(15%), 18(18%), 25(25%), 6(6%),4(4%) and 16(16%) patients had increased level of aspartate amino transferase, alanine amino transferase, alkaline phosphatase direct bilirubin, total bilirubin, creatinine, urea and triglyceride respectively. The mean value serum aspartate amino transferase, alanine amino transferase, alkaline phosphatase, total bilirubin, triglyceride were significantly higher in visceralleishmaniasis patients than in healthy controls, but the mean value of serum urea and totalcholesterol were significantly lower in visceral leishmaniasis patients than healthy controls. Conclusions: The finding of this study concluded that visceral leishmaniasis causes significantalterations of clinical chemistry tests like liver and lipid profile tests.This alterations could becontributed to the immune complex formed during infection with visceral leishmaniasis. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/21270 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Kidney function Test, lipid profile test, Liver function Test, visceral leishmaniasis | en_US |
| dc.title | Assessment of Selected Clinical Chemistry Test Alterations and Associated Risk Factors among Visceral Leishmaniasis Patients Attending at Kahsay Abera and Mearg Hospitals Western Tigrai, Northern Ethiopia, 2019: a Comperative Study | en_US |
| dc.type | Thesis | en_US |