Assessment of selected clinical chemistry test alterations and associated risk factors among visceral leishmaniasis patients attending at Kahsay Abera and Mearg Hospitals Western Tigrai, Northern Ethiopia, 2019: a comperative study
| dc.contributor.advisor | Dr.Wolde, Mistire ( PhD, associate professor ) | |
| dc.contributor.advisor | Dr. Tsegaye, Aster(PhD, associate professor ) | |
| dc.contributor.author | Tesfanchal, Brhane | |
| dc.date.accessioned | 2020-05-21T13:26:55Z | |
| dc.date.accessioned | 2023-11-06T08:56:32Z | |
| dc.date.available | 2020-05-21T13:26:55Z | |
| dc.date.available | 2023-11-06T08:56:32Z | |
| dc.date.issued | 2019-06 | |
| dc.description.abstract | Introduction: Visceral leishmaniasis causes alterations of lipid metabolism and associated with hypochlesterolemia and severe hypertriglyceridemia. Hepatic dysfunction and life threating hepatitis is associated with visceral leishmaniasis. Kidney damage is frequently associated with increased morbidity and mortality in visceral leishmaniasis patients. However there is no published data on the effect of visceral leishmaniasis to kidney, liver, and lipid profiles in Ethiopia particularly in the study area. Objective: To assess selected clinical chemistry test alterations and associated risk factors among visceral leishmaniasis patients attending at Kahsay Abera and Mearg Hospitals Western Tigrai, Northern Ethiopia from November 2018 -March 2019. Method: Institutional based comparative cross sectional study was conducted from November 2018 to March 2019 in Kahsay Abera and Mearg Hospitals, Western Tigrai, Northern Ethiopia. A total of 100 visceral leishmaniasis patients and 100 control groups working in Kahsay Abera and Mearg Hospitals without visceral leishmaniasis were selected by using convenient sampling techniques. The samples were processed and analysed by Mindray 200E automated clinical chemistry analyzer. Data was entered and analyzed using SPSS Version 23. Descrpptive satatisticss, independent-test, binary logistic regressions were used for data analysis. P values < 0.05 were considerd as statistically significant at 95% confidence level. Result: From 100 visceral leishmaniasis 9(9%), 10 (10%), 15(15%), 18(18%), 25(25%), 6(6%), 4(4%) and 16(16%) patients had increased level of aspartate amino transferase, alanine amino transferase, alkaline phosphatase direct bilirubin, total bilirubin, creatinine, urea and triglyceride respectively. The mean value serum aspartate amino transferase, alanine amino transferase, alkaline phosphatase, total bilirubin, triglyceride were significantly higher in visceral leishmaniasis patients than in healthy controls, but the mean value of serum urea and total cholesterol were significantly lower in visceral leishmaniasis patients than healthy controls. Conclusions: The finding of this study concluded that visceral leishmaniasis causes significant alterations of clinical chemistry tests like liver and lipid profile tests.This alterations could be contributed to the immune complex formed during infection with visceral leishmaniasis. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/21270 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Kidney function Test, lipid profile test, Liver function Test, visceral leishmaniasis | en_US |
| dc.title | Assessment of selected clinical chemistry test alterations and associated risk factors among visceral leishmaniasis patients attending at Kahsay Abera and Mearg Hospitals Western Tigrai, Northern Ethiopia, 2019: a comperative study | en_US |
| dc.type | Thesis | en_US |