Assessment of selected clinical chemistry test alterations and associated risk factors among visceral leishmaniasis patients attending at Kahsay Abera and Mearg Hospitals Western Tigrai, Northern Ethiopia, 2019: a comperative study
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Date
2019-06
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Addis Abeba University
Abstract
Introduction: Visceral leishmaniasis causes alterations of lipid metabolism and associated with
hypochlesterolemia and severe hypertriglyceridemia. Hepatic dysfunction and life threating
hepatitis is associated with visceral leishmaniasis. Kidney damage is frequently associated with
increased morbidity and mortality in visceral leishmaniasis patients. However there is no
published data on the effect of visceral leishmaniasis to kidney, liver, and lipid profiles in
Ethiopia particularly in the study area.
Objective: To assess selected clinical chemistry test alterations and associated risk factors
among visceral leishmaniasis patients attending at Kahsay Abera and Mearg Hospitals Western
Tigrai, Northern Ethiopia from November 2018 -March 2019.
Method: Institutional based comparative cross sectional study was conducted from November
2018 to March 2019 in Kahsay Abera and Mearg Hospitals, Western Tigrai, Northern Ethiopia.
A total of 100 visceral leishmaniasis patients and 100 control groups working in Kahsay Abera
and Mearg Hospitals without visceral leishmaniasis were selected by using convenient sampling
techniques. The samples were processed and analysed by Mindray 200E automated clinical
chemistry analyzer. Data was entered and analyzed using SPSS Version 23. Descrpptive
satatisticss, independent-test, binary logistic regressions were used for data analysis. P values <
0.05 were considerd as statistically significant at 95% confidence level.
Result: From 100 visceral leishmaniasis 9(9%), 10 (10%), 15(15%), 18(18%), 25(25%), 6(6%),
4(4%) and 16(16%) patients had increased level of aspartate amino transferase, alanine amino
transferase, alkaline phosphatase direct bilirubin, total bilirubin, creatinine, urea and triglyceride
respectively. The mean value serum aspartate amino transferase, alanine amino transferase,
alkaline phosphatase, total bilirubin, triglyceride were significantly higher in visceral
leishmaniasis patients than in healthy controls, but the mean value of serum urea and total
cholesterol were significantly lower in visceral leishmaniasis patients than healthy controls.
Conclusions: The finding of this study concluded that visceral leishmaniasis causes significant
alterations of clinical chemistry tests like liver and lipid profile tests.This alterations could be
contributed to the immune complex formed during infection with visceral leishmaniasis.
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Keywords
Kidney function Test, lipid profile test, Liver function Test, visceral leishmaniasis