Microbial Profile, Drug Susceptibility Pattern and Associated Risk factor of Urinary Tract Infection in Intensive Care Unit Patients at Public Hospitals, Addis Ababa, Ethiopia
| dc.contributor.advisor | Bitew Adane | |
| dc.contributor.author | Bizuayehu Hiwot | |
| dc.date.accessioned | 2021-11-22T07:57:19Z | |
| dc.date.accessioned | 2023-11-06T08:57:05Z | |
| dc.date.available | 2021-11-22T07:57:19Z | |
| dc.date.available | 2023-11-06T08:57:05Z | |
| dc.date.issued | 2021-10 | |
| dc.description.abstract | Background; Healthcare-associated urinary tract infections are one of the most commoncomplications in hospitalized patients particularly in intensive care unit patients. Both bacteriaand yeast, are implicated as the etiological agents of urinary tract infections. Objective: To determine the spectrum of the etiology (bacterial and yeast), risk factors, andantimicrobial susceptibility patterns of urinary tract infections patients admitted in intensive careunit in public Hospitals at Addis Ababa Ethiopia. Methods: A cross-sectional study was conducted from September 2020 to December 2020 inAddis Ababa public Hospitals’ intensive care unit patients. By using convenient sampling method a total of 220 patients included. To assess Socio-demographic status and associated risk factors of participant we used a structured questionnaire. Urine specimens were collected fromstudy participant, sent to Ethiopian public health institution for microbiological investigation andantimicrobial susceptibility testing. The data was analyzed by SPSS software version 23. Results: Out of 220 urine samples 113 (51.4%) were culture positive of which 20.9% wasbacteriuria while 19.1% was candiduria and 11.4% by mixed culture. The most commonorganism isolated was Candida albicans 29 (21.01%) followed by Enterococcus spp andCandida krusei 18 (13.1%) for each. Ampicillin, Ceftriaxone, and Cefotaxime highly resisted bymost Gram-negative bacteria. Amikacin, Meropenem and, Imipenem were the most active drugsagainst Gram-negative bacteria. Penicillin is resisted by Gram-positive bacteria whereasNitrofurantin best drug of choice for Gram-positive bacteria. Number of admission days inIntensive Care Unit, diabetes millets and Injury found to be risk factors for urinary tractinfection. Female sex, and antibiotic use also a predisposing factor for urinary tract infectioncaused by yeast. Conclusion and Recommendation: The overall prevalence of bacteriuria/ candiduria was51.4% with high drug resistance of bacterial isolate. This implies that, UTI is a significantproblem in different public Hospitals’ intensive care unit patients in Addis Ababa. Thus,Hospitals may need revise their infection prevention practices to prevent the transmission ofresistant bacteria in Intensive Care Unit. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/28820 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Intensive Care Unit, Urinary Tract Infection, Bacteria, Yeast, Addis Ababa, Ethiopia | en_US |
| dc.title | Microbial Profile, Drug Susceptibility Pattern and Associated Risk factor of Urinary Tract Infection in Intensive Care Unit Patients at Public Hospitals, Addis Ababa, Ethiopia | en_US |
| dc.type | Thesis | en_US |