Bacterial Bloodstream Infections and their Antimicrobial Susceptiblity Pattern among Hiv/Aids Patients At Felege Hiwot Referral Hospital, Bahir Dar, Amahara Regional State, North West Ethiopia
| dc.contributor.advisor | Bitew Adane | |
| dc.contributor.author | Jemal Mohabaw | |
| dc.date.accessioned | 2018-07-02T08:15:45Z | |
| dc.date.accessioned | 2023-11-06T08:57:46Z | |
| dc.date.available | 2018-07-02T08:15:45Z | |
| dc.date.available | 2023-11-06T08:57:46Z | |
| dc.date.issued | 2017-04 | |
| dc.description.abstract | Background: Bacterial bloodstream infections are important opportunistic infections which causehigh morbidity and mortality among HIV infected individuals. Bacterial bloodstream infectionsamong HIV/AIDS Patients in Ethiopia is poorly known. Therefore, determining the etiologicalagents of bacterial bloodstream infections and their in vitro antimicrobialsusceptibility patternamong HIV infected patients in Ethiopia is one of the highest priorities. Objective: The aimed of this study was to determine the extent of bacterial bloodstream infectionsand their in vitro antimicrobial susceptibility pattern among HIV/AIDS patients attending ART-clinic from July 15, 2016 to December 15, 2016 G.C at Felege Hiwot Referral Hospital, Bahir Dar,Amhara National Regional State North West Ethiopia. Methods and Materials: A hospital based cross sectional study was conduct among 384 HIV/AIDS patients attending ART- clinic at Felege Hiwot Referral Hospital during the studyperiod. Venous blood samples were collected under strict aseptic condition. Collected bloodsamples were inoculated on blood culture bottles and incubated aerobically at 37o c for seven daysfor the presence of visible sign of microbial growth. Sub cultures were done on the BAP, CAP andMAC (Oxoid). Microorganisms were isolated and identified using standard biochemicaltechniques. Antimicrobial susceptibility tests for each isolated bacteria were determined by discdiffusion method. Quality of the data was assured through standard operational procedures (SOPs).Data was entered, checked for completeness and analyzed using SPSS version 20. Result: This study confirmed that among HIV/AIDS patients, 123 (32%) were infected withbacteremia. Prevalence of blood stream infection was higher in 1-14 years of age group (53.8%)than other age group. Higher percentage of positive blood culture isolates among HIV/AIDSpatients having CD4 count of <200 cells/μL (76.5%) and used of intravenous catheter (68.6%).Themajor isolates were Staphylococcus aureus 49.3% (38/77), Coagulase Negative Staphylococcus35% (n=27/77) and Klebsiella pneumoniae 41.3% (19/46). Majority of isolates 50(40.7%) wereresistant to five and above antimicrobial agents Conclusion: Prevalence of bacterial blood stream infections (32%) among HIV/AIDS patients washigher in this study. Positive blood culture isolates was higher among hospitalized HIV/AIDSpatients with intravenous catheter and low CD4+ lymphocyte count. The most leading pathogenswere S. aureus, CONS and K. pneumonia and majority of isolates were multidrug resistant bacteria. Key words: Bacteremia, HIV, Antimicrobial Susceptibility patter | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/5308 | |
| dc.language.iso | en | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | Bacteremia Antimicrobial Susceptibility patter | en_US |
| dc.title | Bacterial Bloodstream Infections and their Antimicrobial Susceptiblity Pattern among Hiv/Aids Patients At Felege Hiwot Referral Hospital, Bahir Dar, Amahara Regional State, North West Ethiopia | en_US |
| dc.type | Thesis | en_US |