Synthesis, In vitro Antimicrobial and In silico Studies of Sulfonated Derivatives of Carvacrol
No Thumbnail Available
Date
2025-06-05
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa University
Abstract
The emergence of new pathogens and antimicrobial resistance pose significant challenges in treating infectious diseases. These ongoing challenges necessitate the discovery of new drugs. In medicinal chemistry research, carvacrol has become a focus of research as a lead compound due to its multifaceted pharmacological activities particularly its notable antimicrobial activity. Additionally, numerous studies have highlighted the substantial antibacterial potential of sulfonated compounds including sulfonic acids and sulfonate esters. Consequently, this study aimed to synthesize sulfonate derivatives of carvacrol, assess their in vitro antimicrobial activity against 26 bacterial and 4 fungal strains and conduct an in silico analysis
Description
Keywords
Carvacrol, antimicrobial activity, antimicrobial resistance, antibacterial activity, antifungal activity, sulfonated carvacrol, synthesis, in vitro, in silico studies