Prevalence of Streptococcus Agalactaie (GBS) In Pregnant Women and its effect on Outcome of Neonates at Zewditu Memorial Hospital, Addis Ababa,Ethiopia
| dc.contributor.advisor | Desta, Kassu (MSc,phD fellow Associate Professor) | |
| dc.contributor.author | Mustefa, Semira | |
| dc.date.accessioned | 2021-12-01T06:27:03Z | |
| dc.date.accessioned | 2023-11-06T08:57:10Z | |
| dc.date.available | 2021-12-01T06:27:03Z | |
| dc.date.available | 2023-11-06T08:57:10Z | |
| dc.date.issued | 2021-06 | |
| dc.description.abstract | Background: Group B streptococcus (GBS) is gram-positive coccus which is a normal flora of the intestines, vagina or rectum and around 25% of healthy women carry this bacteria without showing any symptom. Bacteraemia, endometritis, amnionitis and urinary tract infection are major cause of bacterial infections caused by GBS in pregnant women in perinatal time, and in neonates it causes sepsis and meningitis. New born get infected through intra-amniotic route or at time of delivery. Objective: To determine GBS prevalence in pregnant women and outcome of neonates in Zewditu Memorial Hospital Addis Ababa Methods: A cross-sectional study design conducted at Zewditu hospital in city of Addis Ababa, Ethiopia from January 2019 to June 2019. A total of 192 pregnant women participated on isolation of group B S.agalactiae. For GBS isolation from vaginal swabs and antimicrobial susceptibility pattern standard operating procedures were followed. Culture, gram stain, catalase reaction and CAMP test, and testing for their susceptibility to antimicrobial agents were performed. All collected data was organized and tabulated using SPSS version 20, Multiple Logistic regression analysis was used to see the association between variables finally the results was summarized by using tables. Results: The age was between 18 to 38 years with a mean of 28.34 ± 3.66 years. From 192 pregnant mothers 30(15.6%) were GBS culture positive. The highest participation 161(83.9%) recorded between the ages of 25-35 years. From all participants the highest 70(36.4%) were house wives. GBS colonization showed a statistically significant association with primary level of maternal education and newborn birth weight. High susceptible of GBS isolate was seen to penicillin G & chloramphenicol (93.3%) for each, ampicillin, and ceftriaxone (90%) each, following vancomycin (80%) and erythromycin (70%). Relatively, GBS showed high resistance to tetracycline (86.7 %), ciprofloxacin (46.7 %) and clindamycin (33.3%). In this study the babies born to women with GBS colonization had statically significant association with clinical sepsis and low birth weight. Conclusion: In this study, the overall prevalence of GBS colonization was 15.6%. Primary educational level and low birth weight was statistically significant with GBS colonization. This study used to give attention during management of pregnant women by making GBS culture as one of routine diagnosis during ANC follow up and to prevent newborn infection by early detection. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/29044 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Group B streptococcus, prevalence, pregnant women, Ethiopia | en_US |
| dc.title | Prevalence of Streptococcus Agalactaie (GBS) In Pregnant Women and its effect on Outcome of Neonates at Zewditu Memorial Hospital, Addis Ababa,Ethiopia | en_US |
| dc.type | Thesis | en_US |