Role of 18F-Fluorodeoxyglucose–Positron Emission Tomography Before, During and After Treatment in T cell and Nk-Cell Lymphomas: A Retrospective Study from Pascale Hospital, Napoli, Italy 2022 G.C.
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Date
2023-02
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Addis Ababa University
Abstract
Background: Over the past years, 18F- FDG PET has emerged as an efficient tool to assess
Hodgkin’s lymphoma and diffuse large B-cell lymphoma’s response to treatment. 18F- FDG PET
is both sensitive and specific for initial staging in T cell /Natural killer cell lymphomas. However,
the predictive value of early or post-therapy 18F- FDG PET remains unknown.
Objective: Therefore, the objective of this study was to assess the role of 18F- FDG PET before,
during and after Treatment in T cell and Natural killer cell lymphomas.
Method: A facility-based descriptive retrospective cohort study design was employed. A total of
57 sample populations was selected using purposive sampling technique among patients visiting
the nuclear medicine department of the hospital. A quantitative method of data collection was
deployed using a data abstraction tool. Data was entered and analyzed using statistical software
SPSS for windows V 26.0. The verbal ethical clearance was obtained from National Cancer
Institute of Napoli.
Result: The result showed that 25 (61%) were males. About 17 (41.5%) of index cases were in the
age group “61-75”, and the mean (+SD) age of respondents was 57.8 (±15.4). All 100% of the
index cases have been diagnosed with biopsy proven disease and PET/CT also showed positivity
on all the index cases.
Discussion: Findings of this study revealed that metabolic parameters like SUVmax and whole-
body metabolic tumor volume at the time of the diagnostic, interim and post treatment 18F- FDG
PET scans does not predict disease progression of T cell /Natural killer cell lymphomas in the
index cases. In addition, Sociodemographic variables such as sex and age on top of clinical
parameters such as Ann Arbor staging at the time of diagnosis, primary lesion location, ECOG and
international prognostic index (IPI) does not seem to have statistical correlation with that of disease
progression.
Recommendation: It is recommended to conduct the study in other centers as well as amending
the limitation of our study challenges.
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Keywords
18F-fluorodeoxyglucose, positron emission tomography, T-cell lymphoma, T/NK neoplasm.