Role of 18F-Fluorodeoxyglucose–Positron Emission Tomography Before, During and After Treatment in T cell and Nk-Cell Lymphomas: A Retrospective Study from Pascale Hospital, Napoli, Italy 2022 G.C.
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Date
2023-02
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Addis Ababa University
Abstract
Background: Over the past years, 18F- FDG PET has emerged as an efficient tool to assessHodgkin’s lymphoma and diffuse large B-cell lymphoma’s response to treatment. 18F- FDG PETis both sensitive and specific for initial staging in T cell /Natural killer cell lymphomas. However,the predictive value of early or post-therapy 18F- FDG PET remains unknown.
Objective: Therefore, the objective of this study was to assess the role of 18F- FDG PET before,during and after Treatment in T cell and Natural killer cell lymphomas.
Method: A facility-based descriptive retrospective cohort study design was employed. A total of57 sample populations was selected using purposive sampling technique among patients visitingthe nuclear medicine department of the hospital. A quantitative method of data collection wasdeployed using a data abstraction tool. Data was entered and analyzed using statistical softwareSPSS for windows V 26.0. The verbal ethical clearance was obtained from National CancerInstitute of Napoli.
Result: The result showed that 25 (61%) were males. About 17 (41.5%) of index cases were in theage group “61-75”, and the mean (+SD) age of respondents was 57.8 (±15.4). All 100% of theindex cases have been diagnosed with biopsy proven disease and PET/CT also showed positivity on all the index cases.Discussion: Findings of this study revealed that metabolic parameters like SUVmax and whole-body metabolic tumor volume at the time of the diagnostic, interim and post treatment 18F- FDG PET scans does not predict disease progression of T cell /Natural killer cell lymphomas in theindex cases. In addition, Sociodemographic variables such as sex and age on top of clinicalparameters such as Ann Arbor staging at the time of diagnosis, primary lesion location, ECOG andinternational prognostic index (IPI) does not seem to have statistical correlation with that of disease progression.
Recommendation: It is recommended to conduct the study in other centers as well as amending the limitation of our study challe
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Keywords
18F-fluorodeoxyglucose, positron emission tomography, T-cell lymphoma, T/NK neoplasm.