Pediatrics and Child Health

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Browsing Pediatrics and Child Health by Subject "Benzanthine penicillin,patients,Heart disease"

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    Prevalence of Benzanthine Penicillin Adverse Reaction in Patients with Rheumatic Heart Disease Taking Monthly Benzanthine Penicillin Injection:A Cross-sectional Survey
    (Addis Abeba University, 2021-10) Mekonnen, Hanna; Dr.Moges, Tamrat (Associate professor of pediatrics and child health and pediatric cardiologist)
    Background: Rheumatic Heart disease (RHD) is by far the most important form of acquired heart disease in children and young adults and continues to be a health problem living in many low and middle-income countries and especially in sub-Saharan Africa. Several strategies have been implemented for rheumatic fever and RHD control. These include primary, primordial and secondary prevention. Benzathine penicillin G (BPG) secondary antibiotic prophylaxis (SAP) has been shown to reduce the risk of ARF recurrences and the development or worsening of RHD with well-established effectiveness. Despite BPG favorable safety profile, a few severe adverse events have been reported and these serious adverse reactions can have a devastating effect on RHD control programs. Objective: This study was aimed at assessing the magnitude of the problem of adverse drug reaction due to benzantine penicillin and its contributing factor Method: A retrospective cross-sectional study was done among pediatric and adult patients who are diagnosed to have CRVHD(chronic rheumatic valvular heart disease) and on follow-up at pediatric and cardiac clinic respectively and taking monthly benzathine penicillin who came for follow-up from December 2020. to October 2021. The data were entered and analyzed by using SPSS version 25. Data collection was conducted exclusively by the principal investigator through telephone interview.Descriptive statistics were employed to summarize the data, and data were presented using Tables and Figures. Binary logistic regression analysis was done to assess predicting factors associated with benzathine penicillin adverse reaction. A p-value <0.05 was considered as statistically significant. Result: A total of 460 pediatric and adult patients who fulfilled the inclusion criteria were enrolled. The prevalence of benzathine penicilline adverse reaction is 21%. The strength of association of both dependent and independent variables was assessed using odds ratio and 95%CI. Accordingly, participants whose age is in the range of 15-18 years had 3.2 fold increased risk to develop benzathine penicillin adverse reaction (AOR=3.2, 95%CI=1.07, 18.62) and age range of 18-30 years had 9.2 fold times increased risk to develop adverse drug reaction when compared to age range of 5-14 years. Conclusion: In this study, Adverse drug reaction of benzanthine penicillin G is common. Factors which are significantly associated with high rate of adverse reaction are age range of 1530,female sex and self and family history of allergy.