Pediatrics and Child Health

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Browsing Pediatrics and Child Health by Subject "Anti-tuberculosis drug-induced liver injury"

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    Prevalence and associated risk factors of anti-tuberculosis drug induced liver injury among children seen in Tikur Anbessa Specialized Hospital
    (Addis Ababa University, 2024-04) Fikre,Mehret; Sani,Elham(Dr.)
    Background: Treatment of patients with tuberculosis (TB) requires careful monitoring for a variety of adverse drug effects. Anti-tuberculosis drug-induced liver injury (ATLI) is one of the most frequent and serious toxic effects during TB treatment. In children, it is less common than adults, but can develop at any age or any dosage of anti-TB drugs, with signs and symptoms frequently overlooked in many cases. As compared to adults were various factors are reported to be associated with higher risk to develop ATLI, in children, susceptibility related to ATLI have been studied insufficiently. Objective: This study aimed to determine the prevalence and associated risk factors of ATLI among children taking anti-TB therapy in Tikur Anbessa Specialized Hospital (TASH), Pediatric Infectious Disease Clinic (PIDC) from January 1, 2021 - December 31, 2022. Method: Hospital-based retrospective cross-sectional study was conducted in a total of 144 selected patients at PIDC from January 1, 2021 - December 31, 2022 G.C. Data was collected by using a standard checklist through Open Data Kit (ODK) form from the patients’ cards and analyzed using SPSS version 27 software package. Mean, and standard deviation were used to describe continuous data, and frequency and percentage were used to describe categorical data. To identify factors associated with ATLI bivariate and multivariable binary logistic regression analyses were done. Statistical significance was considered at level of significance of 5%, and adjusted odds ratio (AOR) with 95% confidence interval (CI) was used to present the estimates of the strength of the association. Result: Among the 144 cases, ATLI was detected in 8 patients, with a prevalence of 5.6 %. Age group 5-15 years [AOR= 0.061; 95% CI: 0.007 – 0.52] and severe acute malnutrition [AOR=13.2; 95% CI: 1.38 -126.3; p-value 0.025] were significantly associated with ATLI prevalence. Conclusion: This study indicated that close monitoring of ATLI should be performed for children with severe acute malnutrition receiving anti-TB therapy.