Browsing by Author "Wordofa, Moges(M.Sc)"

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    Assessment of some Hematological Parameters of Hypertensive Patients in Public Hospitals of Harar, Eastern Ethiopia: A Comparative Cross-sectional Study
    (Addis Abeba University, 2021-02) Sileshi, Beza; Uregessa, Fekadu (M.Sc, Assistant professor, PhD Candidate); Wordofa, Moges(M.Sc)
    Background: Hypertension is a major health problem worldwide and it’s associated with increased risk of cardiovascular disease. Even though hypertension has impact on hematological parameters and alteration of hematological indices may indicate increased risk to cardiovascular diseases, the relationship between hematological parameters and hypertension is little studied. Objective: To compare hematological parameters between hypertensive patients and normotensive adult groups from January 1 to March 30 at Hiwot Fana specialized university hospitals and Jugel hospitals, Harar, eastern Ethiopia. Methods: Institutional based comparative cross-sectional study was conducted from January 1 to March 30 2020 at Jugel and Hiwot Fana hospital, Harar, eastern Ethiopia. Convenient sampling technique was used to recruit 102 hypertensive patients from 2 hospitals and 102 healthy controls from blood bank. Participant’s socio-demographic and clinical information were collected using pre-tested semi structured questionnaire. Blood sample was collected and analyzed by Beckman Coulter DxH 500 analyzer for complete blood count. Data was entered and analyzed using SPSS 20. Independent t-test and Mann Whitney u-test were used for comparison between groups. Spearman’s correlation was used for correlation test. P values less than 0.05 was considered the level of significance. Result: 102 hypertensive and 102 healthy controls were enrolled in this study. 61.8 % of participants were females. The median ± IQR value of WBC, Hgb, HCT, RDW and MPV were significantly higher in hypertension group compared to apparently healthy normotensive groups. Additionally, RBC, HCT and RDW showed statistically significant positive correlations with blood pressure indices (systolic and diastolic). WBC count and RDW were significantly positively correlated with Body mass index. Duration of illness in hypertension patients was also significantly correlated with PLT and MPV. Conclusion: The median values of WBC, Hgb, HCT, RDW and MPV were significantly higher compared to apparently healthy normotensive individuals. Hence, it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated with hematological aberrations. However, further longitudinal studies are required to understand hypertensive associated changes in hematological parameters.
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    Assessment of the relationship between some hematological parameters and blood glucose level and its role as predictors of glycemic control among diabetes mellitus patients attending at ALERT hospital, Addis Ababa, Ethiopia
    (Addis Abeba University, 2021-05) Biresaw, Wubalem; Tamir, Zemenu (MSc, PhD fellow, Assistant Professor); Wordofa, Moges(M.Sc); Kebede, Beruk(Senior GP)
    Introduction: Good glycemic control is the main recommendation to prevent the development of diabetic complications. Recently, hematological parameters became renewed interest in the clinical diagnosis and management of diabetes mellitus. Objective: the objective of this study was to assess selected hematological parameters as predictors of glycemic control and its correlation with blood glucose level among diabetes mellitus patients at ALERT hospital, Addis Ababa, Ethiopia. Methods: A cross-sectional study was conducted between February to August, 2020 among 422 diabetic patients attending at ALERT hospital to assess the utility of selected hematological parameters as indicators of glycemic control association with FBS. Diabetic patients fulfilling the inclusion criteria were selected using convenient sampling technique. Cell-Dyn Ruby and Cobasc331 analyzer were used. Data were analyzed using SPSS version 25 and Chi-square test was used to assess association of dependent and independent variables. ROC was employed to evaluate the utility of hematological parameters for glycemic control. Result: Of the 422diabetic patients enrolled in the study, 242(57.4%) were females and 180 (42.6%) were males. ROC analysis result for MCH (AUC=0.647 (95% CI=0.5750.719)), HCT(AUC=0.599 (95% CI=0.508-0.689)), and MCV(AUC=0.662 (95% CI=0.588-0.736)), cut points were >29.55pg, >45.05%, and >90.25fl for MCH, HCT, and MCV, respectively.HCT(r=0.15), MCV(r=0.189),and RDW (r=0.156) showed positive correlation with HbA1C. Correlation of hematological parameters with FBS indicated that RBC (r=0.147), HCT(r=0.112), and MPV (r=0.134) showed positive correlation with FBS. Conclusion: HCT, RDW, MCH, and MCV had positive correlation with HbA1C; whereas, RBC, Hb, HCT, and MPV had positive correlation with FBS. HCT, MCV and MCH are identified as the most sensitive and specific predictors for glycemic control.