Assessment of some Hematological Parameters of Hypertensive Patients in Public Hospitals of Harar, Eastern Ethiopia: A Comparative Cross-sectional Study
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Date
2021-02
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Addis Abeba University
Abstract
Background: Hypertension is a major health problem worldwide and it’s associated with
increased risk of cardiovascular disease. Even though hypertension has impact on hematological
parameters and alteration of hematological indices may indicate increased risk to cardiovascular
diseases, the relationship between hematological parameters and hypertension is little studied.
Objective: To compare hematological parameters between hypertensive patients and
normotensive adult groups from January 1 to March 30 at Hiwot Fana specialized university
hospitals and Jugel hospitals, Harar, eastern Ethiopia.
Methods: Institutional based comparative cross-sectional study was conducted from January 1
to March 30 2020 at Jugel and Hiwot Fana hospital, Harar, eastern Ethiopia. Convenient sampling
technique was used to recruit 102 hypertensive patients from 2 hospitals and 102 healthy controls
from blood bank. Participant’s socio-demographic and clinical information were collected using
pre-tested semi structured questionnaire. Blood sample was collected and analyzed by Beckman
Coulter DxH 500 analyzer for complete blood count. Data was entered and analyzed using SPSS
20. Independent t-test and Mann Whitney u-test were used for comparison between groups.
Spearman’s correlation was used for correlation test. P values less than 0.05 was considered the
level of significance.
Result: 102 hypertensive and 102 healthy controls were enrolled in this study. 61.8 % of
participants were females. The median ± IQR value of WBC, Hgb, HCT, RDW and MPV were
significantly higher in hypertension group compared to apparently healthy normotensive groups.
Additionally, RBC, HCT and RDW showed statistically significant positive correlations with
blood pressure indices (systolic and diastolic). WBC count and RDW were significantly positively
correlated with Body mass index. Duration of illness in hypertension patients was also
significantly correlated with PLT and MPV.
Conclusion: The median values of WBC, Hgb, HCT, RDW and MPV were significantly higher
compared to apparently healthy normotensive individuals. Hence, it is important to assess
hematological parameters for hypertensive individuals which may help to prevent complications
associated with hematological aberrations. However, further longitudinal studies are required to
understand hypertensive associated changes in hematological parameters.
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Keywords
Blood pressure, Hypertension, Hematological parameters, Harar, Ethiopia