Assessment of some Hematological Parameters of Hypertensive Patients in Public Hospitals of Harar, Eastern Ethiopia: A Comparative Cross-sectional Study

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Date

2021-02

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Addis Abeba University

Abstract

Background: Hypertension is a major health problem worldwide and it’s associated with increased risk of cardiovascular disease. Even though hypertension has impact on hematological parameters and alteration of hematological indices may indicate increased risk to cardiovascular diseases, the relationship between hematological parameters and hypertension is little studied. Objective: To compare hematological parameters between hypertensive patients and normotensive adult groups from January 1 to March 30 at Hiwot Fana specialized university hospitals and Jugel hospitals, Harar, eastern Ethiopia. Methods: Institutional based comparative cross-sectional study was conducted from January 1 to March 30 2020 at Jugel and Hiwot Fana hospital, Harar, eastern Ethiopia. Convenient sampling technique was used to recruit 102 hypertensive patients from 2 hospitals and 102 healthy controls from blood bank. Participant’s socio-demographic and clinical information were collected using pre-tested semi structured questionnaire. Blood sample was collected and analyzed by Beckman Coulter DxH 500 analyzer for complete blood count. Data was entered and analyzed using SPSS 20. Independent t-test and Mann Whitney u-test were used for comparison between groups. Spearman’s correlation was used for correlation test. P values less than 0.05 was considered the level of significance. Result: 102 hypertensive and 102 healthy controls were enrolled in this study. 61.8 % of participants were females. The median ± IQR value of WBC, Hgb, HCT, RDW and MPV were significantly higher in hypertension group compared to apparently healthy normotensive groups. Additionally, RBC, HCT and RDW showed statistically significant positive correlations with blood pressure indices (systolic and diastolic). WBC count and RDW were significantly positively correlated with Body mass index. Duration of illness in hypertension patients was also significantly correlated with PLT and MPV. Conclusion: The median values of WBC, Hgb, HCT, RDW and MPV were significantly higher compared to apparently healthy normotensive individuals. Hence, it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated with hematological aberrations. However, further longitudinal studies are required to understand hypertensive associated changes in hematological parameters.

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Keywords

Blood pressure, Hypertension, Hematological parameters, Harar, Ethiopia

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