Assessment of some Hematological Parameters of Hypertensive Patients in Public Hospitals of Harar, Eastern Ethiopia: A Comparative Cross-sectional Study
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Date
2021-02
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Addis Abeba University
Abstract
Background: Hypertension is a major health problem worldwide and it’s associated withincreased risk of cardiovascular disease. Even though hypertension has impact on hematologicalparameters and alteration of hematological indices may indicate increased risk to cardiovasculardiseases, the relationship between hematological parameters and hypertension is little studied.
Objective: To compare hematological parameters between hypertensive patients andnormotensive adult groups from January 1 to March 30 at Hiwot Fana specialized university hospitals and Jugel hospitals, Harar, eastern Ethiopia.
Methods: Institutional based comparative cross-sectional study was conducted from January 1to March 30 2020 at Jugel and Hiwot Fana hospital, Harar, eastern Ethiopia. Convenient sampling technique was used to recruit 102 hypertensive patients from 2 hospitals and 102 healthy controlsfrom blood bank. Participant’s socio-demographic and clinical information were collected usingpre-tested semi structured questionnaire. Blood sample was collected and analyzed by BeckmanCoulter DxH 500 analyzer for complete blood count. Data was entered and analyzed using SPSS20. Independent t-test and Mann Whitney u-test were used for comparison between groups.Spearman’s correlation was used for correlation test. P values less than 0.05 was considered the level of significance.
Result: 102 hypertensive and 102 healthy controls were enrolled in this study. 61.8 % ofparticipants were females. The median ± IQR value of WBC, Hgb, HCT, RDW and MPV were significantly higher in hypertension group compared to apparently healthy normotensive groups.Additionally, RBC, HCT and RDW showed statistically significant positive correlations withblood pressure indices (systolic and diastolic). WBC count and RDW were significantly positivelycorrelated with Body mass index. Duration of illness in hypertension patients was alsosignificantly correlated with PLT and MPV.
Conclusion: The median values of WBC, Hgb, HCT, RDW and MPV were significantly highercompared to apparently healthy normotensive individuals. Hence, it is important to assesshematological parameters for hypertensive individuals which may help to prevent complicationsassociated with hematological aberrations. However, further longitudinal studies are required tounderstand hypertensive associated changes in hematological parameters.
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Blood pressure, Hypertension, Hematological parameters, Harar, Ethiopia