Assessment of the Relationship Between Some Hematological Parameters and Blood Glucose Level and Its Role as Predictors of Glycemic Control among Diabetes Mellitus Patients Attending at ALERT hospital, Addis Ababa, Ethiopia
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Date
2021-05
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Addis Abeba University
Abstract
Introduction: Good glycemic control is the main recommendation to prevent thedevelopment of diabetic complications. Recently, hematological parameters became renewed interest in the clinical diagnosis and management of diabetes mellitus.
Objective: the objective of this study was to assess selected hematological parameters aspredictors of glycemic control and its correlation with blood glucose level amongdiabetes mellitus patients at ALERT hospital, Addis Ababa, Ethiopia.
Methods: A cross-sectional study was conducted between February to August, 2020 among 422 diabetic patients attending at ALERT hospital to assess the utility of selected hematological parameters as indicators of glycemic control association with FBS.Diabetic patients fulfilling the inclusion criteria were selected using convenient samplingtechnique. Cell-Dyn Ruby and Cobasc331 analyzer were used. Data were analyzed usingSPSS version 25 and Chi-square test was used to assess association of dependent andindependent variables. ROC was employed to evaluate the utility of hematological parameters for glycemic control.
Result: Of the 422diabetic patients enrolled in the study, 242(57.4%) were females and180 (42.6%) were males. ROC analysis result for MCH (AUC=0.647 (95% CI=0.5750.719)),HCT(AUC=0.599 (95% CI=0.508-0.689)), and MCV(AUC=0.662 (95%CI=0.588-0.736)), cut points were >29.55pg, >45.05%, and >90.25fl for MCH, HCT, andMCV, respectively.HCT(r=0.15), MCV(r=0.189),and RDW (r=0.156) showed positivecorrelation with HbA1C. Correlation of hematological parameters with FBS indicatedthat RBC (r=0.147), HCT(r=0.112), and MPV (r=0.134) showed positive correlation withFBS.
Conclusion: HCT, RDW, MCH, and MCV had positive correlation with HbA1C;whereas, RBC, Hb, HCT, and MPV had positive correlation with FBS. HCT, MCV andMCH are identified as the most sensitive and specific predictors for glycemic control.
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Keywords
Glycemic control, HbA1c, diabetes mellitus