Assessment of the relationship between some hematological parameters and blood glucose level and its role as predictors of glycemic control among diabetes mellitus patients attending at ALERT hospital, Addis Ababa, Ethiopia
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Date
2021-05
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Addis Abeba University
Abstract
Introduction: Good glycemic control is the main recommendation to prevent the
development of diabetic complications. Recently, hematological parameters became
renewed interest in the clinical diagnosis and management of diabetes mellitus.
Objective: the objective of this study was to assess selected hematological parameters as
predictors of glycemic control and its correlation with blood glucose level among
diabetes mellitus patients at ALERT hospital, Addis Ababa, Ethiopia.
Methods: A cross-sectional study was conducted between February to August, 2020
among 422 diabetic patients attending at ALERT hospital to assess the utility of selected
hematological parameters as indicators of glycemic control association with FBS.
Diabetic patients fulfilling the inclusion criteria were selected using convenient sampling
technique. Cell-Dyn Ruby and Cobasc331 analyzer were used. Data were analyzed using
SPSS version 25 and Chi-square test was used to assess association of dependent and
independent variables. ROC was employed to evaluate the utility of hematological
parameters for glycemic control.
Result: Of the 422diabetic patients enrolled in the study, 242(57.4%) were females and
180 (42.6%) were males. ROC analysis result for MCH (AUC=0.647 (95% CI=0.5750.719)),
HCT(AUC=0.599 (95% CI=0.508-0.689)), and MCV(AUC=0.662 (95%
CI=0.588-0.736)), cut points were >29.55pg, >45.05%, and >90.25fl for MCH, HCT, and
MCV, respectively.HCT(r=0.15), MCV(r=0.189),and RDW (r=0.156) showed positive
correlation with HbA1C. Correlation of hematological parameters with FBS indicated
that RBC (r=0.147), HCT(r=0.112), and MPV (r=0.134) showed positive correlation with
FBS.
Conclusion: HCT, RDW, MCH, and MCV had positive correlation with HbA1C;
whereas, RBC, Hb, HCT, and MPV had positive correlation with FBS. HCT, MCV and
MCH are identified as the most sensitive and specific predictors for glycemic control.
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Keywords
Glycemic control, HbA1c, diabetes mellitus