Browsing by Author "Gizaw, Solomon Tebeje(PhD)"

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    Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter Pylori Infection
    (Addis Abeba University, 2021-06) Baye, Gelagey; Menon, Menakath (Ph.D.); Gizaw, Solomon Tebeje(PhD)
    Introduction: H. pylori are gram-negative, microaerophilic helical-shaped bacteria with multiple flagella and commonly exist in the stomach. This infection may cause significant mucosal inflammation and damage, leading to ulcers in the stomach. It can also affect organ systems external to the gastrointestinal tract. To assess cardiovascular risk factors and to predict cardiovascular disorders, we are evaluating and comparing lipid profile and hs-CRP levels between H. pylori-positive and negative patients. Objectives: To evaluate lipid profile and hs-CRP levels in dyspeptic patients with and without H. pylori infection. Methods: Hospital-based comparative cross-sectional study was conducted from September 2020 – January 2021 at Debre Markos town. Fifty H. pylori-positive and 50 H. pylori-negative patients were included. Socio-demographic data were assessed by using a structured questionnaire and it was checked for completeness and entered into SPSS version 25.0 Software. Both descriptive and inferential statistics were used in our study. The association between variables was determined by the chi-square test and Pearson correlation. Serum lipid profiles were compared by using a t-test and one-way ANOVA between groups but, hs-CRP levels were compared by using Mann-Whitney U-test between groups since the data wasn’t follow normal distribution. A p-value < 0.05 was considered statistically significant. Result: The mean serum HDL values were 37.54 ± 7.98 mg/dL and 43.12 ± 7.86 mg/dL for H. pylori-positive and negative dyspeptic patients, respectively, and the median of serum hs-CRP levels were 6.29 mg/L and 3.35 mg/L for H. pylori-positive and negative dyspeptic patients, respectively, with the p-value < 0.05 for both HDL and hs-CRP levels. Conclusion: Serum HDL levels were significantly lower in H. pylori-positive dyspeptic patients than negative dyspeptic patients, but serum hs-CRP levels were significantly higher in H. pyloripositive dyspeptic patients than negative dyspeptic patients. Therefore, H. pylori-positive dyspeptic patients are potentially at higher risk for cardiovascular diseases than the negative.
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    Evaluation of Serum Lipid Profiles, Uric Acid and High Sensitivity Creactive Protein Levels among Pregnancy-induced Hypertension
    (Addis Abeba University, 2021-04) Girma, Bilisuma; Gizaw, Solomon Tebeje(PhD)
    Background: Pregnancy-induced hypertension is characterized by an elevation of blood pressure ≥140/90 mmHg as well as the presence/absence of proteinuria and/or edema during pregnancy. Pregnancy-induced hypertension in women is the main problems in developing countries including Ethiopia. Since it is one of the major contributors to maternal and prenatal mortality, the biochemical profiling of these cases are required to provide adequate information to clinicians, health researchers and policy-makers in seeking of potential interventions. Objective: We aimed to evaluate serum lipid profiles, uric acid and high sensitivity C-reactive protein levels among pregnancy-induced hypertension and compared to normotensive pregnant women attending at Ambo University Referral Hospital, Oromia Region, Western Ethiopia. Methods and Materials: A case-control study design and convenient sampling method were used to evaluate serum lipid profile, uric acid and high sensitivity C-reactive protein among pregnancyinduced hypertension and compared to normotensive pregnant women attending at Ambo University Referral Hospital. After we obtained informed consent from pregnant women who visited at ANC service clinic in Ambo University Referral Hospital, about two spoonsful of (35mL) blood was collected and automated Cobas c311 analyzer for Clinical Chemistry was used for laboratory analysis. Then data was analyzed by SPSS version 25. While Student’s t-test was used to compare the mean value of continuous variables, Ch-square was used to compare the relationship of categorical variables between two groups. Significance level was set at the P˂ 0.05 and confidence interval of 95%. Result: Our result showed that while the mean±SD of serum lipid profiles (TC, TG, LDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C), uric acid and hs-CRP were significantly elevated in pregnancy-induced hypertension, HDL-C was decreased in pregnancy-induced hypertension compared to normotensive pregnant women (P<0.05). Conclusion: The lipid profiles (except HDL-C, which was significantly decreased), uric acid and hs-CRP were significantly increased in pregnancy-induced hypertension than normotensive pregnant women, indicating that dyslipidemia, hyperuricemia and inflammation could be an integral part in the pathogenesis of pregnancy-induced hypertension. Therefore, we should consider these potential biomarkers to further research in seeking of interventions in PIH patients.