Evaluation of Serum Lipid Profiles, Uric Acid and High Sensitivity Creactive Protein Levels among Pregnancy-induced Hypertension
No Thumbnail Available
Date
2021-04
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba University
Abstract
Background: Pregnancy-induced hypertension is characterized by an elevation of blood pressure
≥140/90 mmHg as well as the presence/absence of proteinuria and/or edema during pregnancy.
Pregnancy-induced hypertension in women is the main problems in developing countries including
Ethiopia. Since it is one of the major contributors to maternal and prenatal mortality, the
biochemical profiling of these cases are required to provide adequate information to clinicians,
health researchers and policy-makers in seeking of potential interventions.
Objective: We aimed to evaluate serum lipid profiles, uric acid and high sensitivity C-reactive
protein levels among pregnancy-induced hypertension and compared to normotensive pregnant
women attending at Ambo University Referral Hospital, Oromia Region, Western Ethiopia.
Methods and Materials: A case-control study design and convenient sampling method were used
to evaluate serum lipid profile, uric acid and high sensitivity C-reactive protein among pregnancyinduced
hypertension and compared to normotensive pregnant women attending at Ambo
University Referral Hospital. After we obtained informed consent from pregnant women who
visited at ANC service clinic in Ambo University Referral Hospital, about two spoonsful of (35mL)
blood
was
collected
and
automated
Cobas c311 analyzer for Clinical Chemistry was used
for laboratory analysis. Then data was analyzed by SPSS version 25. While Student’s t-test was
used to compare the mean value of continuous variables, Ch-square was used to compare the
relationship of categorical variables between two groups. Significance level was set at the P˂ 0.05
and confidence interval of 95%.
Result: Our result showed that while the mean±SD of serum lipid profiles (TC, TG, LDL-C,
TC/HDL-C, TG/HDL-C, LDL-C/HDL-C), uric acid and hs-CRP were significantly elevated in
pregnancy-induced hypertension, HDL-C was decreased in pregnancy-induced hypertension
compared to normotensive pregnant women (P<0.05).
Conclusion: The lipid profiles (except HDL-C, which was significantly decreased), uric acid and
hs-CRP were significantly increased in pregnancy-induced hypertension than normotensive
pregnant women, indicating that dyslipidemia, hyperuricemia and inflammation could be an
integral part in the pathogenesis of pregnancy-induced hypertension. Therefore, we should
consider these potential biomarkers to further research in seeking of interventions in PIH patients.
Description
Keywords
Pregnancy-induced hypertension, lipid profiles, uric acid, inflammation, Ethiopia.