Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter Pylori Infection
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Date
2021-06
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Addis Abeba University
Abstract
Introduction: H. pylori are gram-negative, microaerophilic helical-shaped bacteria with
multiple flagella and commonly exist in the stomach. This infection may cause significant
mucosal inflammation and damage, leading to ulcers in the stomach. It can also affect organ
systems external to the gastrointestinal tract. To assess cardiovascular risk factors and to predict
cardiovascular disorders, we are evaluating and comparing lipid profile and hs-CRP levels
between H. pylori-positive and negative patients.
Objectives: To evaluate lipid profile and hs-CRP levels in dyspeptic patients with and without
H. pylori infection.
Methods: Hospital-based comparative cross-sectional study was conducted from September
2020 – January 2021 at Debre Markos town. Fifty H. pylori-positive and 50 H. pylori-negative
patients were included. Socio-demographic data were assessed by using a structured
questionnaire and it was checked for completeness and entered into SPSS version 25.0 Software.
Both descriptive and inferential statistics were used in our study. The association between
variables was determined by the chi-square test and Pearson correlation. Serum lipid profiles
were compared by using a t-test and one-way ANOVA between groups but, hs-CRP levels were
compared by using Mann-Whitney U-test between groups since the data wasn’t follow normal
distribution. A p-value < 0.05 was considered statistically significant.
Result: The mean serum HDL values were 37.54 ± 7.98 mg/dL and 43.12 ± 7.86 mg/dL for H.
pylori-positive and negative dyspeptic patients, respectively, and the median of serum hs-CRP
levels were 6.29 mg/L and 3.35 mg/L for H. pylori-positive and negative dyspeptic patients,
respectively, with the p-value < 0.05 for both HDL and hs-CRP levels.
Conclusion: Serum HDL levels were significantly lower in H. pylori-positive dyspeptic patients
than negative dyspeptic patients, but serum hs-CRP levels were significantly higher in H. pyloripositive
dyspeptic patients than negative dyspeptic patients. Therefore, H. pylori-positive
dyspeptic patients are potentially at higher risk for cardiovascular diseases than the negative.
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Keywords
H. pylori, Dyspepsia, Lipid profile, hs-CRP, Inflammation, Cardiovascular diseases