Browsing by Author "Dagne,Andualem"

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    Perioperative outcomes and associated factors of patients with hepatic resection, in Central Ethiopia: a multicenter prospective cohort study.
    (Addis Ababa University, 2023-06) Dagne,Andualem; Abdurahman,Zeki(Ass.Prof.)
    Introduction: As a relatively recent experience practiced only in a few tertiary centers across Ethiopia, the perioperative outcome of patients with hepatic resection is barely known. The main objective of this study is to assess perioperative outcomes and associated factors among patients treated with hepatic resections from July 1, 2022 – June 30, 2023, at tertiary hospitals in Addis Ababa, Ethiopia. Methods: It is multi-center prospective cohort study. Data were collected regarding demographics, comorbidities, the extent of resection, intraoperative findings, perioperative morbidity, and mortality. Data was entered into epidata version 3.1 and exported to SPSS version 26 for descriptive analysis and statistical analyses using binary logistic regression. Result: A total of 76 patients underwent hepatic resection, there were 44 females and 32 males. One-third (32.9%) of these patients had underlying liver disease. The main indication was primary hepatic cancer in 65.8% with HCC in 55.3%. The majority (82.9%) of patients had anatomic-based hepatic resections. Major hepatectomy was performed in 34.2% of patients. The mean duration of surgery was 3.2±1.23 hr., the length of hospital stay was 6.04 ± 3.35 days while the median blood loss was 800ml (IQR 500-1000 ml), and 40.8% of the patients required transfusions. Overall 30- day mortality and morbidity were 3.9% and 32.9% respectively. Morbidity was higher in patients requiring blood transfusion (p=0.008) and malignant disease indications (p= 0.071) although not statistically significant. Conclusion: The perioperative morbidity and mortality of hepatic resection are consistent with the other published literatures. The requirement for blood transfusion and malignant disease indications were associated with higher morbidity.
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    The pattern of clinicopathologic presentation of gall bladder cancer patients managed at Tikur Anbessa specialized hospital from April 1, 2018, to March 31, 2023, Addis Ababa, Ethiopia: a retrospective cross-sectional study.
    (Addis Ababa University, 2023-06) Dagne,Andualem; Nigussie,Shimelis(Ass.Prof.)
    Background: Gallbladder cancer (GBC) is a rare tumor with a very poor prognosis. It is often incidentally found during routine cholecystectomy for gall stone or diagnosed at the advanced clinical stage at the time of presentation. In Ethiopia, no published data assessed the clinicopathologic presentation and the management approach of patients with gall bladder cancer. Objective: The main objective of this study was to assess the pattern of clinicopathologic presentation of gallbladder cancer patients managed at Tikur Anbessa Specialized Hospital from April 1, 2018, to March 31, 2023, in Addis Ababa, Ethiopia. Methods: Facility based retrospective cross-sectional study was conducted on the pattern of clinicopathologic presentation of gallbladder cancer patients managed at Tikur Anbessa Specialized Hospital from April 1, 2018, to March 31, 2023, in Addis Ababa, Ethiopia. Secondary data were extracted from patients’ clinical charts and recorded to a pre-tested checklist. Data was entered into epidata version 3.1 and exported to SPSS version 26 for descriptive analysis using frequency tables, mean, median and standard deviations. Result: During the study period a total 70 gallbladder cancer cases were studied. The mean age at presentation was 56.5 ± 12.2 years and most of the patients were females with a 1.9:1 F: M ratio. The Most (82.9%) common presenting feature was abdominal pain with a median duration of symptoms of 3months (IQR 5.7 months). About 12.8% of patients were found incidentally. Close to half (47.2%) of the patients were having metastasis, with liver involvement accounting for 63.6% and non-regional nodes for 30.3% of metastasis. The remaining 31.4% were resectable and 21.4% of patients were locally unresectable. GB mass lesion is the most frequent imaging feature while gallstones were detected in 50% of cases. Surgical exploration was performed in 35.7% of patients, the rest majority were managed with supportive care (35.7%) and palliative chemotherapy (18.6%). Adenocarcinoma was the commonest histologic type identified (94.4%). Conclusion: - The prevalence of concomitant gallstones in this study was low compared to other studies. Most of the patients were having either locally advanced or metastatic gall bladder cancer. It requires a high index of suspicion and appropriate imaging in middle age individuals and above who presented with persistent abdominal pain to diagnose gall bladder cancer at the early curative stage