Browsing by Author "Alemu, Jemal(MSc, PhD Candidate)"

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Assessment of Hematological Profile among Adult Clients Visiting for Wellness Service at International Clinical Laboratories, Addis Ababa, Ethiopia
    (Addis Abeba University, 2021-09) Ayalew, Etalemahu; Tsegaye, Aster (MSc, PhD); Alemu, Jemal(MSc, PhD Candidate); Nigussie, Mesfin(MD, Pathologist)
    Background: Hematological profiles are affected by commonly known pathological factors. However, nutritional, behavioral and life style factors may vary those parameters among apparently healthy individuals. Little is known about hematological profile of apparently healthy individuals seeking wellness service in resource limited settings like Ethiopia. Objective: To assess the hematological profile of individuals visiting International Clinical Laboratory (ICL) Wellness service in Addis Ababa, Ethiopia Methods: Institutional based cross-sectional study was conducted from February to April 2020 among 422 apparently healthy study participants. Demographic data were collected using structured questionnaire. Blood samples collected in EDTA tubes were analyzed using Cell-Dyn Ruby 5-Diff hematology analyzer. Data were entered and analyzed using SPSS version 20. Results were compared between categorical variables (age and sex) using parametric tests (Independent t test and ANOVA) for continuous variables. Chi-square and binary logistic regression were used to see the relation between independent variables and hematological abnormalities. P-value less than 0.05 was considered as statistically significant. Result: A total of 422 apparently healthy clients (226 males, 53.6%) were included. Their age ranged from 18 – 87 years, with a median (IQR) age of 43 (35-54) years. The mean+SD of WBC, RBC and PLT counts among males were 5.87+1.73, 5.65+0.62 and 250.38±71.58; while the counts among females were 5.95±1.99, 5.09±0.49 and 276.89±74.13, respectively Hematological parameters RBC (p<0.001), HGB (p<0.001), HCT (p<0.001), and absolute lymphocyte count (p=0.028) were significantly higher in males than females, whereas platelet (p<0.001) and absolute neutrophil count (p=0.012) were significantly higher in female counterparts. There was no statistically significant difference in hematological profiles among the age groups. There was statistically significant variation between mean values in the current study and the reference range in current clinical use. Among the total study participants, 12 (5.3%) males and 11 (5.6%) females had anemia. On the other hand, 7 (3.1%) males and 12 (6.1%) females, 3 (1.3%) males and 2 (1%) females, 1 (0.4%) male and 4 (2%) females were found to be leucopenic, thrombocytopenic and lymphopenic, respectively Conclusion: Hematological parameters of study participants have shown significant variation from the established ones. Thus, further investigation needs to be done to confirm our results and establish reference range applicable for local regions.
  • No Thumbnail Available
    Item
    Prevalence of transfusion transmissible infections, ABO blood grouping and antibody screening among blood donors at Defense Health Main Department Bella Blood Bank Center of Addis Ababa, Ethiopia.
    (Addis Abeba University, 2019-06) Belay, Benyam; Tsegaye, AsterMSc, PhD); Alemu, Jemal(MSc, PhD Candidate); Tamir, Zemenu(MSc, PhD Candidate )
    Background: The presence of blood borne infections in blood cells or plasma of asymptomatic donors is the major risk factors for transmitting infectious agents through blood transfusion.Common infectious agents include Hepatitis B virus,Hepatitis C virus , Human immunodeficiency virus and Syphilis . Objective: To determine prevalence of transfusion transmissible infections ,ABO blood grouping and Antibody screening among blood donors at Defense Health Main Department Bella Blood Bank center of Addis Ababa, Ethiopia. Methodology: A retrospective study on the magnitude of TTIs among blood donors was conducted from January2010 to April2019 at Defense Health Main Department Bella Blood Bank center Addis Ababa, Ethiopia. The socio-demography, TTI, ABO typing and antibody screen data was first entered into Excel spread sheet from the institutions file by removing any identifier, cleaned and then finally exported to SPSS Version24 software for analysis.Proportion and P-value was used to calculate statistical significances. P-value<0.05 was considered as statistically significant. Result: The overall prevalence of TTI was 99(10.8%) out of 927 voluntary donors. The prevalence is 93(11.8%)in male and 6(4.2%) in Female. Majority affected agegroup were 46-58(16.4%) followed by 36-45(10.4).The prevalence of HIV,HBV, HCV and Syphilis was 8(0.9%),46(5%),23(2.5%)and 22(2.4%) respectively.Five out of 927(0.53%)had multiple infections, the most common combinations were HBV-HCV 2(0.21%), HBV-Syphilis 2(0.21%) and Syphilis-HCV 1(0.1%). Antibody screening profile revealed 1(0.1%)positive. Conclusion: Th e overall prevalence of TTI was 10.8. promoting of health education among the donor community and enhancement of voluntary donation is recommended.