Antibiotic Susceptibility Pattern of Neisseria meningitides Isolates from Asymptomatic Carriers in Gurage zone, Southern Ethiopia
No Thumbnail Available
Date
2017-06
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa University
Abstract
Background: Neisseria meningitides represents a pathogen of great public health importance in
both developed and developing countries. Resistance to some antimicrobial agents used either
for therapy of invasive infections or for prophylaxis of case contacts has long been recognized.
However, there is a limited data in relation with the antimicrobial resistance pattern of Neisseria
meningitides in Ethiopia. Therefore; the aim of this study was to assess drug susceptibility
pattern of Neisseria meningitides isolates from asymptomatic carrierers of all age groups at
Meskan and Mareko Districts, Gurage Zone, Southern Nations, Nationalities and Peoples
Regional State Ethiopia.
Methods: Cross-sectional study was conducted on 187 Neisseria meningitides isolates obtained
from MenAfricar project.A total of 4110 study participants from Meskan and Mareko Districts,
Gurage Zone, Southern Nations, Nationalities and Peoples Regional State, Ethiopia were
screened for Neisseria meningitides by the project. Antimicrobial susceptibility test (AST) was
done on stored Neisseria meningitides isolates.The activity of ten antimicrobial agents used for
treatment and prophylaxis of meningococcal disease was investigated. The AST was performed
for Neisseria meningitides isolates according to the criteria of the CLSI guide line by disk
diffusion method. Data was analysed by using SPSS version 20.0 software.
Results: From 187 Neisseria meningitides isolates 8(4.28%) were serogroup X, 24(12.83%)
were serogroup Y, 1(0.53%) was serogroup W135 and 154(82.35%) were non determinant (ND).
Resistance for Cotrimoxazol was high accounting
116(62%)
followed by Ciprofloxacine
112(60%), Cefotaxime 26(14%), Ceftriaxone 24(13%) , Meropenenem 21(11%) , Minocycline
15(8%), Rifampine 14(7.5%), Azithromycine 10(5%), Chloramphenicol 7(4%),Levofloxacin
6(3%) . 102(54.5%) isolates were resistance for more than one drug.
Conclusions: An antimicrobial resistance for Neisseria meningitides isolates from asymptomatic
carriers for the present study is high. Continued surveillance of meningococci for antimicrobial
resistance is necessary to monitor early detection of changes in susceptibility patterns that might
affect recommendations for chemoprophylaxis and treatment.
Key words: Neisseria meningitides, serogroups, sensitivity pattern, drug resistance
Description
Keywords
Neisseria meningitides, Serogroups, Sensitivity pattern, Drug resistance