Comparison of lidocaine and tramadol pre medication in attenuating propofol injection pain in Specialized hospital Addis Ababa Ethiopia
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Date
2018-06
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Addis Ababa Universty
Abstract
Background: Propofol is a widely used drug for induction of anesthesia and often causes local
pain when administered into a peripheral vein it causes severe, sharp, stinging or burning pain on
injection that can be distressing to the patient. Pain on injection induced by Propofol has been
found to be reduced by a preceding injection of lidocaine, premedication with an opiate, use of
large vein speed of injection of Propofol, speed of carrier intravenous fluid.
Objective: To assess the effectiveness of intravenous lidocaine and Tramadol in reducing the
incidence and severity of pain on Propofol injection for adult elective surgical patient in Tikur
Anbessa Specialized hospital, Addis Ababa Ethiopia.
Methods: Comparative cross sectional study design was employed.
A sample of 156 patients divided in to two groups of 78 each were included in the study patients
18-60 years old who underwent elective operation with general anesthesia induced with Propofol
who were premedicated with either lidocaine or Tramadol was included in the study. Patient
interview, chart review and pretested structured questionnaires were employed for data
collection. Collected data was analyzed using SPSS version 20 window analyses was done by
Mann –Whitney U Test and chi square test. P value <0.05 was consider as statistically
significant.
Result: The incidence of Propofol injection pain after pretreatments with lidocaine (n=78) was
23.1% and the incidence of Propofol injection pain after pretreatments with tramadol (n=78) was
34.6% with p- value of 0.112. The severity of pain that the median and intrequartile range of
NRS score were 0(0-2.25) in lidocaine group and 0(0-3) in tramadol group which was
comparable between lidocaine group and tramadol group with no statistically significant
difference between two group with (P 0.669)
Conclusion and Recommendation: Lidocaine and tramadol reduced both incidence and
severity Propofol injection pain. Anesthetist can use both lidocaine and tramadol as pretreatment
for the attenuation of propofol injection pain and further study should be conduct.
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Keywords
Propofol,nesthesia