Sociodemographic Features, Risk Factors, Clinical Characteristics and Treatment Outcomes of Patients with Chronic Portal Vein Thrombosis Seen at TASH and Adera Medical Center during the Period between August 2019 and August 2021, Addis Ababa, Ethiopia
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Date
2021-08
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Addis Abeba University
Abstract
Background:Portal vein thrombosis is the most common cause of extra-hepatic portal vein
obstruction. Its prevalence is variable based on studied population, but is higher in developing
countries than developed countries. PVT is mainly associated with cirrhosis and depends on the
severity of the disease.
Objectives: This study was conducted to assess the socio-demographic features, risk factors,
clinical characteristics and treatment outcomes of patients with chronic portal vein thrombosis
seen at Tikur Anbessa specialized hospital (TASH) and Adera medical center during the period
between August 2019 and August 2021, Addis Ababa, Ethiopia. The study also tried to assess
the difference of presentation and outcome of patients between cirrhotic andnoncirrhoticPortal
vein
thrombosis
(PVT).
Methods and materials: The study will be conducted as a cross sectional cohort descriptive
study in two centers to describe the socio-demographic features risk factors, clinical
characteristics and treatment outcome of PVT in patients following at Gastrointestinal (GI)
outpatient clinic, or admitted at the emergency department (ED), intensive care unit (ICU) or
medical wards in TASH and Adera medical center, Addis Ababa University. Datawas gathered
through review of medical records and a questionnaire regarding their demographic
characteristics, and clinical information including etiology, results of laboratory and imaging
tests.The data was checked for clarity and completeness. Computerized data analysis was
conducted by using SPSS (statistical package for the social sciences) version 26 software.
Results:The mean age at diagnosis was 34.64 (± 11.86) years. Majority of patients in the study
were male (52 (69.3%) Vs 23(30.7%)). Majority of patients (63.9%) had chronic presentation
than acute presentation, which was seen in 36.1%. Majority of patients had normal liver
enzymes and coagulation profile. The most common risk factors identified in this study were
cirrhosis (28%), MPD (17.3%) and intra-abdominal infections (12%). The most common
compilations identified were esophageal varices, portal hypertensive gastropathy, ascites and
gastric varices. Endoscopic variceal band ligation was done, nonselective beta blocker,
anticoagulation was given for 29, 38& 24 patients, respectively. Mortality among the 75
patients were 2.7%, 12 patients were lost to follow up and 61 patients continued follow up.
Mortality was mainly as a result of the underling cirrhosis.
Conclusion: Most Portal vein thrombosis patients in this study had chronic presentations of
symptoms. Mortality of patients with cirrhosis is higher than those without cirrhosis.
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Keywords
Portal vein thrombosis,Patients