Assessment of Hematological Parameters among Asthmatic Patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
| dc.contributor.advisor | Tsegaye Aster | |
| dc.contributor.advisor | Negash Mikias | |
| dc.contributor.advisor | Bekele Amsalu | |
| dc.contributor.author | Jemal Abdu | |
| dc.date.accessioned | 2025-08-13T08:00:31Z | |
| dc.date.available | 2025-08-13T08:00:31Z | |
| dc.date.issued | 2023-06 | |
| dc.description.abstract | Background: Asthma is a chronic inflammatory disease which belongs to the leading causes ofmortality globally. Airway inflammation involves an interaction of many blood cells.Consequently, asthmatic condition can alter blood parameters mainly neutrophil and eosinophil.However, the role of other major leukocyte parameters, red blood cell (RBC) indices and meanplatelet volume (MPV) are less investigated. Objective: To assess hematological parameters among asthmatic patients at Tikur AnbessaSpecialized Hospital, Addis Ababa, Ethiopia Methods: A comparative cross-sectional study was carried out from January to May 2023 atTASH in Addis Ababa, Ethiopia. A total of 320 study participants consisting of 160 asthmatic patients and 160 healthy controls were included using convenient sampling technique. Acompleted blood count (CBC) was analyzed by using Beckman coulter hematology analyzer. Todetermine the erythrocyte sedimentation rate (ESR) Westergren method was used. Data wasanalyzed using the SPSS software (version 26). Independent t-test was used to compare the meanhematological values of the asthmatic patients and healthy controls. Binary logistic regressionwas used to assess the association of asthmatic patients with selected risk factors. Statisticalsignificance was determined at P value less than 0.05. Results: The mean age, percentage of females and resident in urban areas of study participantswere 49.53 and 40.72 years old, 55.0% and 51.2% and 84.4% and 89.4% for cases and controls,respectively. The mean values of all WBC parameters, MPV and ESR with the exception ofplatelet count in asthmatic patients had significant mean difference compared with controlgroups. ESR value, MPV, total WBC count and absolute and relative counts of neutrophil,eosinophil and basophil were significantly high in asthmatic patients compared to controls. On the other hand absolute and relative counts of lymphocytes and monocytes were significantly lower in asthmatic patients. Conclusion: This study demonstrated a statistical significant difference in most of hematological parameters among asthmatic patients than the controls. Therefore, hematological parameters showed significant mean difference should be considered for proper management of asthma. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/6701 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Hematological abnormalities Asthma Neutrophilia Eosinophilia | |
| dc.title | Assessment of Hematological Parameters among Asthmatic Patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia | |
| dc.type | Thesis |