Assessment of Renal Function in Patients with throid Disfunction Attending at Arsho Advanced Medical Laboratory,Addis Abeba ,Ethiopia.
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Date
2015-06
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Addis Ababa University
Abstract
Background: Studies demonstrated that abnormal thyroid functions may result decreased or increased kidney size, kidney weight, and affect renal functions. In this regard, studies on the association of abnormal thyroid functions and renal function tests are scarcely found in Ethiopia to assess renal functions among patients with thyroid dysfunction attending at Arsho Advanced Medical Laboratory, Addis Ababa, Ethiopia
Methodohgy: cross sectional study was conducted from March 21/2015-May 27/2015 at Arsho Advanced Medical Laboratory. During the study period, 71 thyroid dysfunction patients were eligible, and socio demographic data collected by structured questionnaire. Then blood sample was collected for thyroid function tests, renal function and blood electrolyte analysis. The collected data was analyzed by SPSS version 20. ANOVA and binary logistic regression were employed to evaluate the tnean deference and associations of thyroid hormone with renal function and electrolyte balances. Rouh: Of the total 71 study participants, 54(76.1%) females, and mean age of the study participants were 41.9±9.7years of age. Among the study participants, euthyroid participants were relatively higher 29(41%) followed by hypothyroid participants 25(35%). Of the renal function tests, serum uric acid, and creatinine values were significantly decreased in hyperthyroid participants; whereas, eGFR value was significantly increased in hyperthyroid study Meanwhile, from electrolyte balance employed, only serum sodium mean value was significantly increased in hyperthyroid study participants. Binary logistic regression analysis on the association of thyroid dysfunction with electrolyte balance and renal function tests indicated that serum sodium, creatinine, eGFR values and hyperthyroidism have a statistical significant association at AOR Cl of P-0.008); 162360.481-75739, p-0.001), and , P-O.OOI) respectively. Cond"n: current study reveals is, there is a significant association between thyroid abnormalities with renal functions and electrolyte balance. Knowledge Of this significant association has worthwhile value for clinicians, and it may help to improve the health Status Of patients with thyroid abnormality.
Key word Thyroid dysfunction, renal function tests, blood electrolyte
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Keywords
Renal Function , Throid Disfunction